Animal models of major depression: drawbacks and challenges
Major depression is a leading contributor to the global burden of disease. This situation is
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …
The neurobiology of depression and antidepressant action
P Willner, J Scheel-Krüger, C Belzung - Neuroscience & biobehavioral …, 2013 - Elsevier
We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …
Sex-specific transcriptional signatures in human depression
Major depressive disorder (MDD) is a leading cause of disease burden worldwide. While the
incidence, symptoms and treatment of MDD all point toward major sex differences, the …
incidence, symptoms and treatment of MDD all point toward major sex differences, the …
Chronic stress followed by social isolation promotes depressive-like behaviour, alters microglial and astrocyte biology and reduces hippocampal neurogenesis in …
Unpredictable chronic mild stress (UCMS) is one of the most commonly used, robust and
translatable models for studying the neurobiological basis of major depression. Although the …
translatable models for studying the neurobiological basis of major depression. Although the …
Sex differences in nucleus accumbens transcriptome profiles associated with susceptibility versus resilience to subchronic variable stress
GE Hodes, ML Pfau, I Purushothaman… - Journal of …, 2015 - Soc Neuroscience
Depression and anxiety disorders are more prevalent in females, but the majority of
research in animal models, the first step in finding new treatments, has focused …
research in animal models, the first step in finding new treatments, has focused …
Animal models of depression: what can they teach us about the human disease?
Depression is apparently the most common psychiatric disease among the mood disorders
affecting about 10% of the adult population. The etiology and pathogenesis of depression …
affecting about 10% of the adult population. The etiology and pathogenesis of depression …
Novel drug developmental strategies for treatment‐resistant depression
Major depressive disorder is a leading cause of disability worldwide. Because conventional
therapies are ineffective in many patients, novel strategies are needed to overcome …
therapies are ineffective in many patients, novel strategies are needed to overcome …
Central and peripheral inflammation link metabolic syndrome and major depressive disorder
Metabolic syndrome and major depression are two of the most common and debilitating
disorders worldwide, occurring with significant rates of comorbidity. Recent studies have …
disorders worldwide, occurring with significant rates of comorbidity. Recent studies have …
Modeling anxiety using adult zebrafish: a conceptual review
Zebrafish (Danio rerio) are rapidly emerging as a useful animal model in neurobehavioral
research. Mounting evidence shows the suitability of zebrafish to model various aspects of …
research. Mounting evidence shows the suitability of zebrafish to model various aspects of …
Glyphosate based-herbicide exposure affects gut microbiota, anxiety and depression-like behaviors in mice
Recently, a number of studies have demonstrated the profound relationship between gut
microbiota (GM) alterations and behavioral changes. Glyphosate-based herbicides (GBH) …
microbiota (GM) alterations and behavioral changes. Glyphosate-based herbicides (GBH) …