Intratumoural microbiota: a new frontier in cancer development and therapy

Y Cao, H **a, X Tan, C Shi, Y Ma, D Meng… - … and Targeted Therapy, 2024 - nature.com
Human microorganisms, including bacteria, fungi, and viruses, play key roles in several
physiological and pathological processes. Some studies discovered that tumour tissues …

Dysbiosis in inflammatory bowel disease: pathogenic role and potential therapeutic targets

PT Santana, SLB Rosas, BE Ribeiro, Y Marinho… - International journal of …, 2022 - mdpi.com
Microbe–host communication is essential to maintain vital functions of a healthy host, and its
disruption has been associated with several diseases, including Crohn's disease and …

The microbiota–gut–brain axis and neurodevelopmental disorders

Q Wang, Q Yang, X Liu - Protein & Cell, 2023 - academic.oup.com
The gut microbiota has been found to interact with the brain through the microbiota–gut–
brain axis, regulating various physiological processes. In recent years, the impacts of the gut …

[HTML][HTML] Stress, epigenetics, and aging: unraveling the intricate crosstalk

Z Wu, J Qu, W Zhang, GH Liu - Molecular Cell, 2024 - cell.com
Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

Microbiota-derived butyrate restricts tuft cell differentiation via histone deacetylase 3 to modulate intestinal type 2 immunity

EM Eshleman, T Rice, C Potter, A Waddell… - Immunity, 2024 - cell.com
Tuft cells in mucosal tissues are key regulators of type 2 immunity. Here, we examined the
impact of the microbiota on tuft cell biology in the intestine. Succinate induction of tuft cells …

[HTML][HTML] Diet-gut microbiota-epigenetics in metabolic diseases: From mechanisms to therapeutics

D Li, Y Li, S Yang, J Lu, X **, M Wu - Biomedicine & Pharmacotherapy, 2022 - Elsevier
The prevalence of metabolic diseases, including obesity, dyslipidemia, type 2 diabetes
mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD), is a severe burden in human …

Emerging role of human microbiome in cancer development and response to therapy: special focus on intestinal microflora

H Sadrekarimi, ZR Gardanova, M Bakhshesh… - Journal of translational …, 2022 - Springer
In recent years, there has been a greater emphasis on the impact of microbial populations
inhabiting the gastrointestinal tract on human health and disease. According to the …

[HTML][HTML] The role of short chain fatty acids in inflammation and body health

Y Du, C He, Y An, Y Huang, H Zhang, W Fu… - International journal of …, 2024 - mdpi.com
Short chain fatty acids (SCFAs), mainly including acetate, propionate and butyrate, are
produced by intestinal bacteria during the fermentation of partially digested and indigestible …

Prebiotic oligofructose protects against high-fat diet-induced obesity by changing the gut microbiota, intestinal mucus production, glycosylation and secretion

P Paone, F Suriano, C Jian, K Korpela… - Gut …, 2022 - Taylor & Francis
Obesity is a major risk factor for the development of type 2 diabetes and cardiovascular
diseases, and gut microbiota plays a key role in influencing the host energy homeostasis …

Hormetic Nutrition and Redox Regulation in Gut–Brain Axis Disorders

M Scuto, F Rampulla, GM Reali, SM Spanò… - Antioxidants, 2024 - mdpi.com
The antioxidant and anti-inflammatory effects of hormetic nutrition for enhancing stress
resilience and overall human health have received much attention. Recently, the gut–brain …