Reticulons (RTNs) are a group of membrane-associated proteins mainly responsible for
sha** the tubular endoplasmic reticulum network, membrane trafficking, inhibition of …

Most of the current therapies, as well as many of the clinical trials, for multiple sclerosis (MS)
target the inflammatory autoimmune processes, but less than 20% of all clinical trials …

Two hallmarks of chronic multiple sclerosis lesions are the absence of significant
spontaneous remyelination and primary as well as secondary neurodegeneration. Both …

Abstract Purpose Oligodendrocytes (OLGs) damage and myelin distraction is considered as
a critical step in many neurological disorders especially multiple sclerosis (MS). Cuprizone …

Background Inhibitory factors have been implicated in the failure of remyelination in
demyelinating diseases. Myelin associated inhibitors act through a common receptor called …

Multiple sclerosis (MS) can progress with neurodegeneration as a consequence of chronic
inflammatory mechanisms that drive neural cell loss and/or neuroaxonal dystrophy in the …

Multiple sclerosis (MS) is a neurodegenerative disease of the central nervous system. The
animal model of MS, experimental autoimmune encephalomyelitis (EAE), is commonly used …

Current therapeutics targeting chronic phases of multiple sclerosis (MS) are considerably
limited in reversing the neural damage resulting from repeated inflammation and …

We have previously reported evidence that Nogo-A activation of Nogo-receptor 1 (NgR1)
can drive axonal dystrophy during the neurological progression of experimental …

Cadherins were originally isolated as calcium-dependent cell adhesion molecules and are
characterized by their cadherin motifs in the extracellular domain. In vertebrates, including …