Since the pioneering work of Elie Metchnikoff and the discovery of cellular immunity, the
phagocytic clearance of cellular debris has been considered an integral component of …

lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids,
particularly omega-6 and-3 fatty acids, to generate a number of bioactive lipid metabolites. A …

Caspase-dependent apoptosis accounts for approximately 90% of homeostatic cell turnover
in the body, and regulates inflammation, cell proliferation, and tissue regeneration,–. How …

Macrophages are considered to contribute to chronic inflammatory diseases such as
rheumatoid arthritis. However, both the exact origin and the role of macrophages in …

Triggering receptor expressed on myeloid cells 2 (TREM2) sustains microglia response to
brain injury stimuli including apoptotic cells, myelin damage, and amyloid β (Aβ) …

In the human body, billions of cells die by apoptosis every day. The subsequent clearance of
apoptotic cells by phagocytosis is normally efficient enough to prevent secondary necrosis …

As its first identified member, Interleukin-12 (IL-12) named a whole family of cytokines. In
response to pathogens, the heterodimeric protein, consisting of the two subunits p35 and …

The clearance of apoptotic cells is an essential process for tissue homeostasis. To this end,
cells undergoing apoptosis must display engulfment signals, such as 'find-me'and 'eat …

Phosphatidylserine recognition receptors are a highly diverse set of receptors grouped by
their ability to recognize the 'eat‐me'signal phosphatidylserine on apoptotic cells. Most of the …

In metazoans, removal of cells in situ is involved in larval maturation, metamorphosis, and
embryonic development. In adults, such cell removal plays a role in the homeostatic …