The immune system is coordinated by an intricate network of stimulatory and inhibitory
circuits that regulate host responses against endogenous and exogenous insults. Disruption …

SUMMARY A significant increase in the incidence of Candida-mediated infections has been
observed in the last decade, mainly due to rising numbers of susceptible individuals …

C-type lectin receptors (CLRs) expressed by myeloid cells constitute a versatile family of
receptors that play a key role in innate immune recognition. Myeloid CLRs exhibit a …

The NF-κB transcription factor is the master regulator of the inflammatory response and is
essential for the homeostasis of the immune system. NF-κB regulates the transcription of …

The bacterial pathogen Helicobacter pylori has co-evolved with humans and colonizes
approximately 50% of the human population, but only causes overt gastric disease in a …

Abstract Interleukin-10 (IL-10), a cytokine with anti-inflammatory properties, has a central
role in infection by limiting the immune response to pathogens and thereby preventing …

Together with proteins and fats, carbohydrates are one of the macronutrients in the human
diet. Digestible carbohydrates, such as starch, starch-based products, sucrose, lactose …

C-type lectin receptors (CLRs) expressed by dendritic cells are crucial for tailoring immune
responses to pathogens. Following pathogen binding, CLRs trigger distinct signalling …

How can probiotic bacteria transduce their health benefits to the host? Bacterial cell surface
macromolecules are key factors in this beneficial microorganism–host crosstalk, as they can …

TLRs play a critical role in the detection of microbes and endogenous “alarmins” to initiate
host defense, yet they can also contribute to the development and progression of …