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[HTML][HTML] Natural-product-based, carrier-free, noncovalent nanoparticles for tumor chemo-photodynamic combination therapy
Z Wang, L Yang - Pharmacological Research, 2024 - Elsevier
Cancer, with its diversity, heterogeneity, and complexity, is a significant contributor to global
morbidity, disability, and mortality, highlighting the necessity for transformative treatment …
morbidity, disability, and mortality, highlighting the necessity for transformative treatment …
Synthetic molecular evolution of antimicrobial peptides
Highlights•Various peptide design methods have facilitated peptide–drug
development.•Only a few peptide therapeutics have entered the antibiotic market in the past …
development.•Only a few peptide therapeutics have entered the antibiotic market in the past …
Mechanistic understanding from molecular dynamics in pharmaceutical research 2: lipid membrane in drug design
We review the use of molecular dynamics (MD) simulation as a drug design tool in the
context of the role that the lipid membrane can play in drug action, ie, the interaction …
context of the role that the lipid membrane can play in drug action, ie, the interaction …
No country for old antibiotics! Antimicrobial peptides (AMPs) as next-generation treatment for skin and soft tissue infection
In recent years, the unprecedented rise of bacterial antibiotic resistance together with the
lack of adequate therapies have made the treatment of skin infections and chronic wounds …
lack of adequate therapies have made the treatment of skin infections and chronic wounds …
Molecular dynamics for antimicrobial peptide discovery
Although antimicrobial resistance is an increasingly significant public health concern, there
have only been two new classes of antibiotics approved for human use since the 1960s …
have only been two new classes of antibiotics approved for human use since the 1960s …
Nanoparticles functionalized ceramic membranes: fabrication, surface modification, and performance
Membrane technologies are used intensively for desalination and wastewater treatment.
Water filtration using ceramic membranes exhibited high performance compared with …
Water filtration using ceramic membranes exhibited high performance compared with …
Aggregation and its influence on the bioactivities of a novel antimicrobial peptide, temporin-PF, and its analogues
Y Zai, X **, Z Ye, C Ma, M Zhou, X Chen… - International Journal of …, 2021 - mdpi.com
Temporin is an antimicrobial peptide (AMP) family discovered in the skin secretion of ranid
frog that has become a promising alternative for conventional antibiotic therapy. Herein, a …
frog that has become a promising alternative for conventional antibiotic therapy. Herein, a …
Serotonin alters the phase equilibrium of a ternary mixture of phospholipids and cholesterol
Unsaturated and saturated phospholipids tend to laterally segregate, especially in the
presence of cholesterol. Small molecules such as neurotransmitters, toxins, drugs etc …
presence of cholesterol. Small molecules such as neurotransmitters, toxins, drugs etc …
Cannabidiol protects mouse hippocampal neurons from neurotoxicity induced by amyloid β-peptide25–35
KCB Salgado, RG de Freitas Nascimento… - Toxicology in Vitro, 2024 - Elsevier
Abstract Alzheimer's disease (AD), the most prevalent form of dementia worldwide, is a
significant health concern, according to the World Health Organization (WHO). The …
significant health concern, according to the World Health Organization (WHO). The …
Integrated design of a membrane‐lytic peptide‐based intravenous nanotherapeutic suppresses triple‐negative breast cancer
Membrane‐lytic peptides offer broad synthetic flexibilities and design potential to the arsenal
of anticancer therapeutics, which can be limited by cytotoxicity to noncancerous cells and …
of anticancer therapeutics, which can be limited by cytotoxicity to noncancerous cells and …