Host entry by gamma-herpesviruses—lessons from animal viruses?

L Gillet, B Frederico, PG Stevenson - Current opinion in virology, 2015 - Elsevier
Highlights•There is no good evidence for oral gammaherpesvirus entry.•Animal viruses can
help us to decipher their human counterparts.•MuHV-4 enters new hosts via the olfactory …

Macrophages drive KSHV B cell latency

A Szymula, G Samayoa-Reyes, S Ogolla, B Liu, S Li… - Cell reports, 2023 - cell.com
Kaposi's sarcoma herpesvirus (KSHV) establishes lifelong infection and persists in latently
infected B cells. Paradoxically, in vitro B cell infection is inefficient, and cells rapidly die …

Interplay of murine gammaherpesvirus 68 with NF-kappaB signaling of the host

B Cieniewicz, AL Santana, N Minkah… - Frontiers in …, 2016 - frontiersin.org
Herpesviruses establish a chronic infection in the host characterized by intervals of lytic
replication, quiescent latency, and reactivation from latency. Murine gammaherpesvirus 68 …

Murine cytomegalovirus exploits olfaction to enter new hosts

HE Farrell, C Lawler, CSE Tan, K MacDonald, K Bruce… - MBio, 2016 - journals.asm.org
Viruses transmit via the environmental and social interactions of their hosts. Herpesviruses
have colonized mammals since their earliest origins, suggesting that they exploit ancient …

A murid gamma-herpesviruses exploits normal splenic immune communication routes for systemic spread

B Frederico, B Chao, JS May, GT Belz, PG Stevenson - Cell host & microbe, 2014 - cell.com
Gamma-herpesviruses (γHVs) are widespread oncogenic pathogens that chronically infect
circulating lymphocytes. How they subvert the immune check-point function of the spleen to …

Indirect CD4+ T cell protection against mouse gamma-herpesvirus infection via interferon gamma

W **e, K Bruce, GT Belz, HE Farrell… - Journal of …, 2024 - journals.asm.org
ABSTRACT CD4+ T cells play a key role in γ-herpesvirus infection control. However, the
mechanisms involved are unclear. Murine herpesvirus type 4 (MuHV-4) allows relevant …

Glycoprotein K8. 1A of Kaposi's sarcoma-associated herpesvirus is a critical B cell tropism determinant independent of its heparan sulfate binding activity

SJ Dollery, RJ Santiago-Crespo, D Chatterjee… - Journal of …, 2019 - journals.asm.org
ABSTRACT B lymphocytes are the major cellular reservoir in individuals infected with
Kaposi's sarcoma-associated herpesvirus (KSHV), and the virus is etiologically linked to two …

A gammaherpesvirus noncoding RNA is essential for hematogenous dissemination and establishment of peripheral latency

ER Feldman, M Kara, LM Oko, KR Grau, BJ Krueger… - MSphere, 2016 - journals.asm.org
Recent intense investigations have uncovered important functions for a diverse array of
novel noncoding RNA (ncRNA) species, including microRNAs (miRNAs) and long …

Alveolar macrophages are a prominent but nonessential target for murine cytomegalovirus infecting the lungs

HE Farrell, C Lawler, MT Oliveira… - Journal of …, 2016 - journals.asm.org
Cytomegaloviruses (CMVs) infect the lungs and cause pathological damage there in
immunocompromised hosts. How lung infection starts is unknown. Inhaled murine CMV …

Engineered commensals for targeted nose-to-brain drug delivery

H Shen, N Aggarwal, B Cui, GW Foo, Y He… - Cell, 2025 - cell.com
Intranasal administration through the olfactory epithelium (OE) presents a direct pathway for
brain-targeted therapeutic delivery, although its feasibility is hampered by the anatomical …