ABC transporters are essential for cellular physiology. Humans have 48 ABC genes
organized into seven distinct families. Of these genes, 44 (in five distinct families) encode for …

Cholangiocytes, the epithelial cells lining the intrahepatic and extrahepatic bile ducts, are
highly specialized cells residing in a complex anatomic niche where they participate in bile …

MXenes, as a novel kind of two-dimensional (2D) materials, were first discovered by Gogotsi
et al. in 2011. Owing to their multifarious chemical compositions and outstanding …

In arbitrary dimension, in the discrete setting of finite-differences we prove a Carleman
estimate for a semi-discrete parabolic operator, in which the large parameter is connected to …

Chemotherapeutics are the most effective treatment for metastatic tumours. However, the
ability of cancer cells to become simultaneously resistant to different drugs—a trait known as …

Effective treatment of metastatic cancers usually requires the use of toxic chemotherapy. In
most cases, multiple drugs are used, as resistance to single agents occurs almost …

▪ Abstract The design of cancer chemotherapy has become increasingly sophisticated, yet
there is no cancer treatment that is 100% effective against disseminated cancer. Resistance …

The transport of specific molecules across lipid membranes is an essential function of all
living organisms and a large number of specific transporters have evolved to carry out this …

Active drug efflux transporters of the ATP binding cassette (ABC)-containing family of
proteins have a major impact on the pharmacological behavior of most of the drugs in use …

The human multidrug resistance-associated protein (MRP) family currently has seven
members. The ability of several of these membrane proteins to transport a wide range of …