The potential impact of neuroimaging and translational research on the clinical management of lacunar stroke
Lacunar infarcts represent one of the most frequent subtypes of ischemic strokes and may
represent the first recognizable manifestation of a progressive disease of the small …
represent the first recognizable manifestation of a progressive disease of the small …
Detection, risk factors, and functional consequences of cerebral microinfarcts
Cerebral microinfarcts are small lesions that are presumed to be ischaemic. Despite the
small size of these lesions, affected individuals can have hundreds to thousands of cerebral …
small size of these lesions, affected individuals can have hundreds to thousands of cerebral …
Cerebral small vessel disease: a review of the pathophysiological mechanisms
Y Hannawi - Translational Stroke Research, 2024 - Springer
Cerebral small vessel disease (cSVD) refers to the age-dependent pathological processes
involving the brain small vessels and leading to vascular cognitive impairment, intracerebral …
involving the brain small vessels and leading to vascular cognitive impairment, intracerebral …
A pathogenic role for IL-10 signalling in capillary stalling and cognitive impairment in type 1 diabetes
Vascular pathology is associated with cognitive impairment in diseases such as type 1
diabetes; however, how capillary flow is affected and the underlying mechanisms remain …
diabetes; however, how capillary flow is affected and the underlying mechanisms remain …
Structural and functional remodeling of the brain vasculature following stroke
Maintenance of cerebral blood vessel integrity and regulation of cerebral blood flow ensure
proper brain function. The adult human brain represents only a small portion of the body …
proper brain function. The adult human brain represents only a small portion of the body …
Multifocal cerebral microinfarcts modulate early Alzheimer's disease pathology in a sex-dependent manner
Alzheimer's disease (AD) constitutes a major cause of dementia, affecting more women than
men. It is characterized by amyloid-β (Aβ) deposition and neurofibrillary tangles (NFTs) …
men. It is characterized by amyloid-β (Aβ) deposition and neurofibrillary tangles (NFTs) …
Functional deficits induced by cortical microinfarcts
Clinical studies have revealed a strong link between increased burden of cerebral
microinfarcts and risk for cognitive impairment. Since the sum of tissue damage incurred by …
microinfarcts and risk for cognitive impairment. Since the sum of tissue damage incurred by …
Cerebral small vessel disease (CSVD)–lessons from the animal models
Cerebral small vessel disease (CSVD) refers to a spectrum of clinical and imaging findings
resulting from pathological processes of various etiologies affecting cerebral arterioles …
resulting from pathological processes of various etiologies affecting cerebral arterioles …
VEGF signaling regulates the fate of obstructed capillaries in mouse cortex
Cortical capillaries are prone to obstruction, which over time, could have a major impact on
brain angioarchitecture and function. The mechanisms that govern the removal of these …
brain angioarchitecture and function. The mechanisms that govern the removal of these …
The severity of microstrokes depends on local vascular topology and baseline perfusion
Cortical microinfarcts are linked to pathologies like cerebral amyloid angiopathy and
dementia. Despite their relevance for disease progression, microinfarcts often remain …
dementia. Despite their relevance for disease progression, microinfarcts often remain …