Highlights•Time-resolved structural information is key to understanding biological
mechanism.•The molecular details of biomolecular catalysis and regulation can be studied …

The concept of indirect or'allosteric'interaction between topographically distinct sites, and the
subsequent 1965 Monod-Wyman-Changeux (MWC) model for the conformational change …

Cooperative interactions play a very important role in both natural and synthetic
supramolecular systems. We report here on the cooperative binding properties of a …

Small-and wide-angle x-ray scattering (SWAXS) and molecular dynamics (MD) simulations
are complementary approaches that probe conformational transitions of biomolecules in …

The 50th anniversary of the classic Monod–Wyman–Changeux (MWC) model provides an
opportunity to survey the broader conceptual and quantitative implications of this …

Allosteric regulation is found across all domains of life, yet we still lack simple, predictive
theories that directly link the experimentally tunable parameters of a system to its input …

Small-angle X-ray scattering (SAXS) is an established technique that provides low-
resolution structural information on macromolecular solutions. Recent decades have …

Biolayer interferometry (BLI) is a well-established laboratory technique for studying
biomolecular interactions important for applications such as drug development. Currently …

Infections caused by Staphylococcus aureus depend on its ability to acquire nutrients. One
essential nutrient is iron, which is obtained from the heme of the human host hemoglobin …

Basic research on hemoglobin has been essential for understanding the origin and
treatment of many hematological disorders due to abnormal hemoglobins. The most …