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Synthesis, in vitro bio-evaluation, and molecular docking study of thiosemicarbazone-based isatin/bis-Schiff base hybrid analogues as effective cholinesterase …
Analogues of isatin/bis-Schiff bases based on thiocarbohydrazone (1–16) were synthesized,
characterised using various methods like NMR and HR-ESI-MS, and then tested against the …
characterised using various methods like NMR and HR-ESI-MS, and then tested against the …
[HTML][HTML] Synthesis, biological evaluation and molecular docking study of pyrimidine based thiazolidinone derivatives as potential anti-urease and anti-cancer agents
Hybrid analogs containing molecules are always the choice of different synthetic researcher
due to their diverse biological applications and significantly more efficient. Heterocyclic …
due to their diverse biological applications and significantly more efficient. Heterocyclic …
[HTML][HTML] Bis-indole based triazine derivatives: synthesis, characterization, in vitro β-glucuronidase anti-cancer and anti-bacterial evaluation along with in silico …
The present work described the synthetic procedure adopted for the synthesis of bis-indole-
based triazine derivatives via a series of reactions. All the compounds were synthesized …
based triazine derivatives via a series of reactions. All the compounds were synthesized …
Unveiling anti-diabetic potential of new thiazole-sulfonamide derivatives: Design, synthesis, in vitro bio-evaluation targeting DPP-4, α-glucosidase, and α-amylase with …
Diabetes mellitus type 2 (T2DM) can be managed by targeting dipeptidyl peptidase-4 (DPP-
4), an enzyme that breaks down and deactivates peptides such as GIP and GLP-1. In this …
4), an enzyme that breaks down and deactivates peptides such as GIP and GLP-1. In this …
[HTML][HTML] The synthesis, in vitro bio-evaluation, and in silico molecular docking studies of pyrazoline–thiazole hybrid analogues as promising anti-α-glucosidase and …
In the present work, a concise library of benzothiazole-derived pyrazoline-based thiazole (1–
17) was designed and synthesized by employing a multistep reaction strategy. The newly …
17) was designed and synthesized by employing a multistep reaction strategy. The newly …
Synthesis and In Vitro α-Amylase and α-Glucosidase Dual Inhibitory Activities of 1,2,4-Triazole-Bearing bis-Hydrazone Derivatives and Their Molecular Docking …
There is an increasing prevalence of diabetes mellitus throughout the world, and new
compounds are necessary to combat this. The currently available antidiabetic therapies are …
compounds are necessary to combat this. The currently available antidiabetic therapies are …
Investigating Novel Thiophene Carbaldehyde Based Thiazole Derivatives as Potential Hits for Diabetic Management: Synthesis, In Vitro and In Silico Approach
This research work is based on synthesis of eleven novel thiazole derivatives (3 a‐k) of
thiophene carbaldehyde. All the synthesized compounds were successfully synthesized …
thiophene carbaldehyde. All the synthesized compounds were successfully synthesized …
Hybrid molecules of thiadiazole-based benzothioate and benzenesulfonothioate: synthesis, structural analysis, and evaluation as potential inhibitors of thymidine …
The thiadiazole-based benzothioate (3a-f) and benzenesulfonothioate (5a-f) hybrid
derivatives were designed and synthesized in a single step reaction. All the synthesized …
derivatives were designed and synthesized in a single step reaction. All the synthesized …
Identification of isobenzofuranone derivatives as promising antidiabetic agents: Synthesis, in vitro and in vivo inhibition of α-glucosidase and α-amylase …
Diabetes mellitus, one of the major health challenges of the 21st century, is associated with
numerous biomedical complications including retinopathy, neuropathy, nephropathy …
numerous biomedical complications including retinopathy, neuropathy, nephropathy …
Synthesis of novel thiazole derivatives containing 3-methylthiophene carbaldehyde as potent anti α-glucosidase agents: In vitro evaluation, molecular docking …
Thiazole derivatives bearing thiophene carbaldehyde have been successfully prepared by
refluxing 3-methylthiophene carbaldehyde with thiosemicarbazide in absolute ethanol …
refluxing 3-methylthiophene carbaldehyde with thiosemicarbazide in absolute ethanol …