The Alba protein family: Structure and function

M Goyal, C Banerjee, S Nag… - Biochimica et Biophysica …, 2016 - Elsevier
Alba family proteins are small, basic, dimeric nucleic acid-binding proteins, which are widely
distributed in archaea and a number of eukaryotes. This family of proteins bears the distinct …

RNA-binding proteins and their role in the regulation of gene expression in Trypanosoma cruzi and Saccharomyces cerevisiae

C Oliveira, H Faoro, LR Alves… - Genetics and molecular …, 2017 - SciELO Brasil
RNA-binding proteins (RBPs) have important functions in the regulation of gene expression.
RBPs play key roles in post-transcriptional processes in all eukaryotes, such as splicing …

Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi

P Smircich, G Eastman, S Bispo, MA Duhagon… - BMC genomics, 2015 - Springer
Background Due to the absence of transcription initiation regulation of protein coding genes
transcribed by RNA polymerase II, posttranscriptional regulation is responsible for the …

RNA-Seq reveals that overexpression of TcUBP1 switches the gene expression pattern toward that of the infective form of Trypanosoma cruzi

KB Sabalette, JR Sotelo-Silveira, P Smircich… - Journal of Biological …, 2023 - ASBMB
Trypanosomes regulate gene expression mainly by using posttranscriptional mechanisms.
Key factors responsible for carrying out this regulation are RNA-binding proteins, affecting …

[HTML][HTML] Regulatory elements involved in the post-transcriptional control of stage-specific gene expression in Trypanosoma cruzi: a review

PR Araújo, SM Teixeira - Memorias do Instituto Oswaldo Cruz, 2011 - SciELO Brasil
Trypanosoma cruzi, a protozoan parasite that causes Chagas disease, exhibits unique
mechanisms for gene expression such as constitutive polycistronic transcription of protein …

Trypanosomatid comparative genomics: contributions to the study of parasite biology and different parasitic diseases

SM Teixeira, RMC Paiva… - … and molecular biology, 2012 - SciELO Brasil
In 2005, draft sequences of the genomes of Trypanosoma brucei, Trypanosoma cruzi and
Leishmania major, also known as the Tri-Tryp genomes, were published. These protozoan …

Protein Synthesis Attenuation by Phosphorylation of eIF2α Is Required for the Differentiation of Trypanosoma cruzi into Infective Forms

RR Tonelli, LS Augusto, BA Castilho, S Schenkman - PloS one, 2011 - journals.plos.org
Chagas' disease is a potentially life-threatening illness caused by the unicellular protozoan
parasite Trypanosoma cruzi. It is transmitted to humans by triatomine bugs where T. cruzi …

Proteomics uncovers novel components of an interactive protein network supporting RNA export in trypanosomes

AH Inoue, PF Domingues, M Serpeloni… - Molecular & Cellular …, 2022 - ASBMB
In trypanosomatids, transcription is polycistronic and all mRNAs are processed by trans-
splicing, with export mediated by noncanonical mechanisms. Although mRNA export is …

Differential Subcellular Localization of Leishmania Alba-Domain Proteins throughout the Parasite Development

A Dupé, C Dumas, B Papadopoulou - PLoS One, 2015 - journals.plos.org
Alba-domain proteins are RNA-binding proteins found in archaea and eukaryotes and
recently studied in protozoan parasites where they play a role in the regulation of virulence …

Protein and mRNA content of TcDHH1‐containing mRNPs in Trypanosoma cruzi

FB Holetz, LR Alves, CM Probst… - The FEBS …, 2010 - Wiley Online Library
In trypanosomatids, the regulation of gene expression occurs mainly at the post‐
transcriptional level. Previous studies have revealed nontranslated mRNA in the …