Exploring Fish Antimicrobial Peptides (Amps): Classification, Biological Activities, and Mechanisms of Action

M Akhavan-Bahabadi, SPH Shekarbi… - International Journal of …, 2024 - Springer
Background Despite the growing productivity of aquaculture, economic losses due to
infectious diseases, environmental pollution, and human safety concerns related to antibiotic …

[HTML][HTML] Sexual dimorphism in fish innate immunity: A functional and transcriptional study in yellowtail kingfish

Y Valero, CF Hurtado, L Mercado - Fish & Shellfish Immunology, 2024 - Elsevier
Sexual dimorphism in immunity has been extensively documented across vertebrates, with
marked contrasts observed in immune responses between males and females. These …

Antimicrobial activity and mechanisms of a derived antimicrobial peptide TroNKL-27 from golden pompano (Trachinotus ovatus) NK-lysin

H Zhang, Z Cao, Q Diao, Y Zhou, J Ao, C Liu… - Fish & Shellfish …, 2022 - Elsevier
NK-lysin, a homologue of granulysin among human, is predominantly found in natural killer
cells and cytotoxic T-lymphocytes, which plays a pivotal part in innate immune responses …

New insight into the biological activity of Salmo salar NK-lysin antimicrobial peptides

L Ortega, C Carrera, C Muñoz-Flores… - Frontiers in …, 2024 - frontiersin.org
NK-lysin is a potent antimicrobial peptide (AMP) with antimicrobial activity against bacteria,
fungi, viruses, and parasites. NK-lysin is a type of granulysin, a member of the saposin-like …

Severe Natural Outbreak of Cryptocaryon irritans in Gilthead Seabream Produces Leukocyte Mobilization and Innate Immunity at the Gill Tissue

L Cervera, C González-Fernández, M Arizcun… - International Journal of …, 2022 - mdpi.com
The protozoan parasite Cryptocaryon irritans causes marine white spot disease in a wide
range of fish hosts, including gilthead seabream, a very sensitive species with great …

[HTML][HTML] Immunity elicited by AMP-encoding plasmids fails to increase the protection of European sea bass against nodavirus

L Cervera, C González-Fernández, D Cano… - Fish & shellfish …, 2023 - Elsevier
Antimicrobial peptides (AMPs) are a potent arm of the innate immune system that can
directly kill pathogens and induce immunomodulation. In the marine aquaculture, European …

[HTML][HTML] NK-lysin peptides ameliorate viral encephalopathy and retinopathy disease signs and provide partial protection against nodavirus infection in European sea …

Y Valero, C González-Fernández, C Cárdenas… - Antiviral Research, 2021 - Elsevier
Antimicrobial peptides (AMP) comprise a wide range of small molecules with direct
antibacterial activity and immunostimulatory role and are proposed as promising substitutes …

Functional characterization of obscure puffer ToNK-lysin: A novel immunomodulator possessing anti-bacterial and anti-inflammatory properties

Y Yang, X Song, N Cui, T Lei, Y Huang, Y Shi… - Fish & Shellfish …, 2023 - Elsevier
NK-lysins are one of the most abundant antimicrobial peptides produced by cytotoxic T
lymphocytes (CTLs) and natural killer cells (NKs), and identified as a new class of …

[HTML][HTML] Synthetic antimicrobial Nkl and Dic peptides are immunomodulatory but only Dic peptide can be therapeutic against nodavirus infection

L Cervera, M Arizcun, L Mercado… - Fish & Shellfish …, 2024 - Elsevier
Aquaculture is a prosperous economic sector threatened by viral infections. Among the
viruses threatening fish culture, Betanodavirus (NNV) is extremely important in the …

[HTML][HTML] Regulation and distribution of European sea bass perforins point to their role in the adaptive cytotoxic response against NNV

MA García-Álvarez, L Cervera, Y Valero… - Fish & Shellfish …, 2024 - Elsevier
Cell-mediated cytotoxicity is a complex immune mechanism that involves the release of
several killing molecules, being perforin (PRF) one of the most important effector players …