Coordinating radiometals of copper, gallium, indium, yttrium, and zirconium for PET and SPECT imaging of disease
TJ Wadas, EH Wong, GR Weisman… - Chemical …, 2010 - ACS Publications
Molecular imaging is the visualization, characterization, and measurement of biological
processes at the molecular and cellular levels in humans and other living systems …
processes at the molecular and cellular levels in humans and other living systems …
[HTML][HTML] Affibody molecules: engineered proteins for therapeutic, diagnostic and biotechnological applications
Affibody molecules are a class of engineered affinity proteins with proven potential for
therapeutic, diagnostic and biotechnological applications. Affibody molecules are small (6.5 …
therapeutic, diagnostic and biotechnological applications. Affibody molecules are small (6.5 …
Transdermal gene delivery
Gene delivery has revolutionized conventional medical approaches to vaccination, cancer,
and autoimmune diseases. However, current gene delivery methods are limited to either …
and autoimmune diseases. However, current gene delivery methods are limited to either …
Affibody molecules as targeting vectors for PET imaging
Affibody molecules are small (58 amino acids) engineered scaffold proteins that can be
selected to bind to a large variety of proteins with a high affinity. Their small size and high …
selected to bind to a large variety of proteins with a high affinity. Their small size and high …
The emerging role of radionuclide molecular imaging of HER2 expression in breast cancer
Targeting of human epidermal growth factor type 2 (HER2) using monoclonal antibodies,
antibody-drug conjugates and tyrosine kinase inhibitors extends survival of patients with …
antibody-drug conjugates and tyrosine kinase inhibitors extends survival of patients with …
PET and SPECT imaging of the EGFR family (RTK class I) in oncology
The human epidermal growth factor receptor family (EGFR-family, other designations: HER
family, RTK Class I) is strongly linked to oncogenic transformation. Its members are …
family, RTK Class I) is strongly linked to oncogenic transformation. Its members are …
Affibody-derived drug conjugates: Potent cytotoxic molecules for treatment of HER2 over-expressing tumors
Patients with HER2-positive tumors often suffer resistance to therapy, warranting
development of novel treatment modalities. Affibody molecules are small affinity proteins …
development of novel treatment modalities. Affibody molecules are small affinity proteins …
ADAPT, a novel scaffold protein-based probe for radionuclide imaging of molecular targets that are expressed in disseminated cancers
Small engineered scaffold proteins have attracted attention as probes for radionuclide-
based molecular imaging. One class of these imaging probes, termed ABD-Derived Affinity …
based molecular imaging. One class of these imaging probes, termed ABD-Derived Affinity …
On the selection of a tracer for PET imaging of HER2-expressing tumors: direct comparison of a 124I-labeled affibody molecule and trastuzumab in a murine xenograft …
A Orlova, H Wållberg, S Stone-Elander… - Journal of Nuclear …, 2009 - Soc Nuclear Med
Human epidermal growth factor receptor type 2 (HER2) is a tyrosine kinase, which is often
overexpressed in many carcinomas. Imaging HER2 expression in malignant tumors can …
overexpressed in many carcinomas. Imaging HER2 expression in malignant tumors can …
Preclinical characterization of a stabilized gastrin-releasing peptide receptor antagonist for targeted cancer theranostics
A Abouzayed, P Kanellopoulos, A Gorislav… - Biomolecules, 2023 - mdpi.com
Radiolabeled gastrin-releasing peptide receptor (GRPR) antagonists have shown great
promise for the theranostics of prostate cancer; however, their suboptimal metabolic stability …
promise for the theranostics of prostate cancer; however, their suboptimal metabolic stability …