In mammals, hematopoietic stem cells (HSCs) engage in hematopoiesis throughout adult
life within the bone marrow, where they produce the mature cells necessary to maintain …

The neuroepithelial stem cell protein, or Nestin, is a cytoskeletal intermediate filament
initially characterized in neural stem cells. However, current extensive evidence obtained in …

We test the hypothesis that glioblastoma harbors quiescent cancer stem cells that evade anti-
proliferative therapies. Functional characterization of spontaneous glioblastomas from …

Adult neurogenic niches harbor quiescent neural stem cells; however, their in vivo identity
has been elusive. Here, we prospectively isolate GFAP+ CD133+(quiescent neural stem …

Mammalian hematopoietic stem cells (HSCs) colonize the bone marrow during late fetal
development, and this becomes the major site of hematopoiesis after birth. However, little is …

The glucocorticoid receptor (Gr, encoded by the gene Grl1) controls transcription of target
genes both directly by interaction with DNA regulatory elements and indirectly by cross-talk …

Mitochondrial morphology is dynamically controlled by a balance between fusion and
fission. The physiological importance of mitochondrial fission in vertebrates is less clearly …

The crucial role of cancer stem cells (CSC s) in the pathology of malignant diseases has
been extensively studied during the last decade. Nestin, a class VI intermediate filament …

Summary Activation of melanocortin-4-receptors (MC4Rs) reduces body fat stores by
decreasing food intake and increasing energy expenditure. MC4Rs are expressed in …

In the vertebrate central nervous system, multipotential cells have been identified in vitro and
in vivo. Defined mitogens cause the proliferation of multipotential cells in vitro, the …