Since first described by Paul Ehrlich in 1878, mast cells have been mostly viewed as
effectors of allergy. It has been only in the past two decades that mast cells have gained …

A standard goal of medicinal chemists has been to discover efficient and potent drug
candidates with specific enzyme-inhibitor abilities. In this regard, boron-based bioactive …

Dendritic cells (DCs) are crucial for mounting allergic airway inflammation, but it is unclear
which subset of DCs performs this task. By using CD64 and MAR-1 staining, we reliably …

Asthma is a T lymphocyte–controlled disease of the airway wall caused by inflammation,
overproduction of mucus and airway wall remodeling leading to bronchial hyperreactivity …

Abstract CD4+ T helper (TH) cells have crucial roles in orchestrating adaptive immune
responses. TH2 cells control immunity to extracellular parasites and all forms of allergic …

Asthma is characterized by chronic lower airway inflammation that results in airway
remodeling, which can lead to a permanent decrease in lung function. The pathophysiology …

The type 2 immune response is critical for host defense against large parasites such as
helminths. On the other hand, dysregulation of the type 2 immune response may cause …

Whether epithelial cells play a role in triggering the immune cascade leading to T helper 2
(TH2)-type allergic inflammation is not known. We show here that human thymic stromal …

Living in a microbe-rich environment reduces the risk of develo** asthma. Exposure of
humans or mice to unmethylated CpG DNA (CpG) from bacteria reproduces these protective …

Dendritic cells (DCs) are central in the orchestration of the various forms of immunity and
tolerance. Their immunoregulatory role mainly relies on the ligation of specific receptors that …