Solute carrier (SLC) transporters—a family of more than 300 membrane-bound proteins that
facilitate the transport of a wide array of substrates across biological membranes—have …

Solute carrier (SLC) membrane transport proteins control essential physiological functions,
including nutrient uptake, ion transport, and waste removal. SLCs interact with several …

Global classification of the human proteins with regards to spatial expression patterns
across organs and tissues is important for studies of human biology and disease. Here, we …

Solute carrier (SLCs) transporters mediate the transport of a broad range of solutes across
biological membranes. Dysregulation of SLCs has been associated with various …

Drug discovery for difficult targets that have large and flat binding sites is often better suited
to compounds beyond the “rule of 5”(bRo5). However, such compounds carry higher …

Membrane-bound solute carrier (SLC) transporter proteins are vital to the human body, as
they sustain homeostasis by moving soluble molecule as nutrients, drugs, and waste across …

The human solute carrier (SLC) transporters are important targets for drug development.
Structure-based drug discovery for SLC transporters requires the description of their …

The kidney plays a vital role in the body's defense against potentially toxic xenobiotics and
metabolic waste products through elimination pathways. In particular, secretory transporters …

How genomic selection enables species to adapt to divergent environments is a
fundamental question in ecology and evolution. We investigated the genomic signatures of …

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with an appalling
prognosis. The failure of anti-inflammatory therapies coupled with the observation that …