The host-adapted human pathogen Neisseria gonorrhoeae is the causative agent of
gonorrhoea. Consistent with its proposed evolution from an ancestral commensal bacterium …

The advent of heme during evolution allowed organisms possessing this compound to
safely and efficiently carry out a variety of chemical reactions that otherwise were difficult or …

Many host-adapted bacterial pathogens contain DNA methyltransferases (mod genes) that
are subject to phase-variable expression (high-frequency reversible ON/OFF switching of …

Since the concentration of free iron in the human host is low, efficient iron-acquisition
mechanisms constitute important virulence factors for pathogenic bacteria. In Gram-negative …

Expanding efforts to develop preventive gonorrhea vaccines is critical because of the dire
possibility of untreatable gonococcal infections. Reverse vaccinology, which includes …

Neisseria gonorrhoeae is a host-adapted pathogen that colonizes primarily the human
genitourinary tract. This bacterium encounters reactive oxygen and reactive nitrogen species …

Symptomatic gonococcal infection, caused by the pathogen Neisseria gonorrhoeae (Gc), is
characterized by the influx of polymorphonuclear leukocytes (PMNs) to the site of infection …

Bacterial two-component systems (TCSs) mediate specific responses to distinct conditions
and/or stresses. TCS interactions are highly specific between cognate partners to avoid …

Iron is both essential for bacterial growth and toxic at higher concentrations; thus, iron
homeostasis is tightly regulated. In Neisseria meningitidis the majority of iron-responsive …

The outer membrane of Gram-negative bacteria functions as a permeability barrier that
protects these bacteria against harmful compounds in the environment. Most nutrients pass …