Boosting human immunology: harnessing the potential of immune organoids
M Moll, D Baumjohann - EMBO Molecular Medicine, 2025 - embopress.org
Studying the human immune system in vivo is challenging and often not possible. Therefore,
most human immunology studies have been predominantly confined to peripheral blood …
most human immunology studies have been predominantly confined to peripheral blood …
The β Common Cytokine Receptor Family Reveals New Functional Paradigms From Structural Complexities
Cytokines are small proteins that are critical for controlling the growth and activity of
hematopoietic cells by binding to cell surface receptors and transmitting signals across …
hematopoietic cells by binding to cell surface receptors and transmitting signals across …
A cost-effective approach for comprehensive analysis of human memory B Cell repertoire: fast isolation of broad neutralizing mAbs to SARS-CoV-2 variants
The SARS-CoV-2 pandemic highlighted the urgent need for innovative methods to study
humoral immune responses and identify monoclonal antibodies (mAbs) with diagnostic and …
humoral immune responses and identify monoclonal antibodies (mAbs) with diagnostic and …
Review of the potential value of serum interleukin levels as prognostic biomarkers of liver failure
Y Lin, GJ Yan, MY Liu, Y Cao, K Zhang… - World Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Liver failure (LF) is prevalent in China and is characterized by complex pathogenesis,
challenging clinical management, poor prognosis, and rising incidence and mortality rates …
challenging clinical management, poor prognosis, and rising incidence and mortality rates …
Potent antitumor activity of a designed interleukin-21 mimic
Long-standing goals of cancer immunotherapy are to activate cytotoxic antitumor T cells
across a broad range of affinities while dampening suppressive regulatory T (Treg) cell …
across a broad range of affinities while dampening suppressive regulatory T (Treg) cell …
IL-9 as a naturally orthogonal cytokine with optimal JAK/STAT signaling for engineered T cell therapy
Arming T cells with a synthetically orthogonal IL-9 receptor (o9R) permits facile engraftment
and potent anti-tumor functions. We considered whether the paucity of natural IL-9R …
and potent anti-tumor functions. We considered whether the paucity of natural IL-9R …