Aptamers are single-stranded DNA or RNA oligonucleotides that can selectively bind to a
specific target. They are generally obtained by SELEX, but the procedure is challenging and …

Computational analysis of RNA sequences constitutes a crucial step in the field of RNA
biology. As in other domains of the life sciences, the incorporation of artificial intelligence …

The performance of a model in machine learning problems highly depends on the dataset
and training algorithms. Choosing the right training algorithm can change the tale of a …

Abstract The Sand Cat Swarm Optimization (SCSO) algorithm is a recently introduced
metaheuristic with balanced behavior in the exploration and exploitation phases. However, it …

Aptamers are artificial nucleic acid ligands that have been employed in various fundamental
studies and applications, such as biological analyses, disease diagnostics, targeted …

RNA-protein interactions of a virus play a major role in the replication of RNA viruses. The
replication and transcription of these viruses take place in the cytoplasm of the host cell; …

Background Drug repurposing aims to detect the new therapeutic benefits of the existing
drugs and reduce the spent time and cost of the drug development projects. The synthetic …

Aptamers can be regarded as efficient substitutes for monoclonal antibodies in many
diagnostic and therapeutic applications. Due to the tedious and prohibitive nature of SELEX …

The inhibition of protein-protein interactions (PPIs) by small molecules is an exciting drug
discovery strategy. Here, we aimed to develop a pipeline to identify candidate small …

Background: Interactions of RNA and DNA with proteins are crucial for elucidating
intracellular processes in living organisms, diagnosing disorders, designing aptamer drugs …