In quantum mechanochemistry, quantum chemical methods are used to describe molecules
under the influence of an external force. The calculation of geometries, energies, transition …

There is an ongoing global shift in pharmaceutical business models from small molecule
drugs to biologics. This increase in complexity is in response to advancements in our …

Background Bleeding contributes to the high mortality of venovenous extracorporeal
membrane oxygenation (vvECMO). The development of acquired von Willebrand syndrome …

Purpose Extracorporeal life support (ECLS) is used for patients with refractory heart failure
with or without respiratory failure. This temporary support is provided by blood pumps which …

During the past several decades, left ventricular assist devices (LVADs) have become a
valuable therapeutic option in the management of advanced systolic heart failure. Durable …

Many sets of forcefield parameters for calcium carbonate (CaCO3) and CaCO3–water
interactions have been developed for thermodynamic calculations, but growing interest in …

Single-molecule force spectroscopy has provided unprecedented insights into protein
folding, force regulation, and function. So far, the field has relied primarily on atomic force …

Chronic thromboembolic pulmonary hypertension (CTEPH) is an important consequence of
pulmonary embolism that is associated with abnormalities in haemostasis. We investigated …

Essentials• Relationship of acquired von Willebrand disease (VWD) and platelet dysfunction
is explored.• Patients with ventricular assist devices and on extracorporeal membrane …

Aims: Acquired Von Willebrand syndrome (AVWS) is an acquired bleeding disorder that has
been reported to aggravate bleeding complications in patients with ventricular assist devices …