Fucose is a 6-deoxy hexose in the l-configuration found in a large variety of different
organisms. In mammals, fucose is incorporated into N-glycans, O-glycans and glycolipids by …

Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a recently defined entity
that includes rare kidney diseases characterized by tubular damage and interstitial fibrosis …

Uromodulin (also known as Tamm-Horsfall protein) is exclusively produced in the kidney
and is the most abundant protein in normal urine. The function of uromodulin remains …

Chronic kidney disease (CKD) has a heritable component and is an important global public
health problem because of its high prevalence and morbidity. We conducted genome-wide …

Hypertension is a heritable and major contributor to the global burden of disease. The sum
of rare and common genetic variants robustly identified so far explain only 1%–2% of the …

Uromodulin, released from tubular cells of the ascending limb into the blood, may be
associated with kidney function. This work studies the relevance of plasma uromodulin as a …

Uromodulin, also known as Tamm-Horsfall protein, represents the predominant urinary
protein in healthy individuals. Over the years, studies have revealed compelling …

Humans excrete uric acid as the final breakdown product of unwanted purine nucleotides.
Urate scavenges potential harmful radicals in our body. However, in conjunction with …

Uromodulin (Tamm–Horsfall protein) is the most abundant protein excreted in the urine
under physiological conditions. It is exclusively produced in the kidney and secreted into the …

Rare autosomal dominant tubulointerstitial kidney disease is caused by mutations in the
genes encoding uromodulin (UMOD), hepatocyte nuclear factor-1β (HNF1B), renin (REN) …