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Mitochondria as signaling organelles control mammalian stem cell fate
RP Chakrabarty, NS Chandel - Cell stem cell, 2021 - cell.com
Recent evidence supports the notion that mitochondrial metabolism is necessary for the
determination of stem cell fate. Historically, mitochondrial metabolism is linked to the …
determination of stem cell fate. Historically, mitochondrial metabolism is linked to the …
The multiple links between actin and mitochondria
TS Fung, R Chakrabarti, HN Higgs - Nature Reviews Molecular Cell …, 2023 - nature.com
Actin plays many well-known roles in cells, and understanding any specific role is often
confounded by the overlap of multiple actin-based structures in space and time. Here, we …
confounded by the overlap of multiple actin-based structures in space and time. Here, we …
Role of mitochondria in radiation responses: epigenetic, metabolic, and signaling impacts
D Averbeck, C Rodriguez-Lafrasse - International journal of molecular …, 2021 - mdpi.com
Until recently, radiation effects have been considered to be mainly due to nuclear DNA
damage and their management by repair mechanisms. However, molecular biology studies …
damage and their management by repair mechanisms. However, molecular biology studies …
The multifaceted regulation of mitophagy by endogenous metabolites
Owing to the dominant functions of mitochondria in multiple cellular metabolisms and distinct
types of regulated cell death, maintaining a functional mitochondrial network is fundamental …
types of regulated cell death, maintaining a functional mitochondrial network is fundamental …
Modulating mitofusins to control mitochondrial function and signaling
E Zacharioudakis, B Agianian, V Kumar MV… - Nature …, 2022 - nature.com
Mitofusins reside on the outer mitochondrial membrane and regulate mitochondrial fusion, a
physiological process that impacts diverse cellular processes. Mitofusins are activated by …
physiological process that impacts diverse cellular processes. Mitofusins are activated by …
Determinants, maintenance, and function of organellar pH
SA Freeman, S Grinstein… - Physiological reviews, 2023 - journals.physiology.org
The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …
Structural basis and regulation of the reductive stress response
AG Manford, EL Mena, KY Shih, CL Gee, R McMinimy… - Cell, 2021 - cell.com
Although oxidative phosphorylation is best known for producing ATP, it also yields reactive
oxygen species (ROS) as invariant byproducts. Depletion of ROS below their physiological …
oxygen species (ROS) as invariant byproducts. Depletion of ROS below their physiological …
Visualization of cristae and mtDNA interactions via STED nanoscopy using a low saturation power probe
Mitochondria are crucial organelles closely associated with cellular metabolism and
function. Mitochondrial DNA (mtDNA) encodes a variety of transcripts and proteins essential …
function. Mitochondrial DNA (mtDNA) encodes a variety of transcripts and proteins essential …
Static lung storage at 10 C maintains mitochondrial health and preserves donor organ function
A Ali, A Wang, RVP Ribeiro, EL Beroncal… - Science Translational …, 2021 - science.org
Cold static preservation on ice (~ 4° C) remains the clinical standard of donor organ
preservation. However, mitochondrial injury develops during prolonged storage, which limits …
preservation. However, mitochondrial injury develops during prolonged storage, which limits …
MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
JC Reynolds, RW Lai, JST Woodhead, JH Joly… - Nature …, 2021 - nature.com
Healthy aging can be promoted by enhanced metabolic fitness and physical capacity.
Mitochondria are chief metabolic organelles with strong implications in aging that also …
Mitochondria are chief metabolic organelles with strong implications in aging that also …