Writing, erasing and reading histone lysine methylations
Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …
many cellular events. Lysine methylations mark various sites on the tail and globular …
The interplay of histone modifications–writers that read
Histones are subject to a vast array of posttranslational modifications including acetylation,
methylation, phosphorylation, and ubiquitylation. The writers of these modifications play …
methylation, phosphorylation, and ubiquitylation. The writers of these modifications play …
Perceiving the epigenetic landscape through histone readers
Post-translational modifications (PTMs) of histones provide a fine-tuned mechanism for
regulating chromatin structure and dynamics. PTMs can alter direct interactions between …
regulating chromatin structure and dynamics. PTMs can alter direct interactions between …
Histone modifications for human epigenome analysis
H Kimura - Journal of human genetics, 2013 - nature.com
Histones function both positively and negatively in the regulation of gene expression, mainly
governed by post-translational modifications on specific amino acid residues. Although …
governed by post-translational modifications on specific amino acid residues. Although …
Transcription shapes genome-wide histone acetylation patterns
Histone acetylation is a ubiquitous hallmark of transcription, but whether the link between
histone acetylation and transcription is causal or consequential has not been addressed …
histone acetylation and transcription is causal or consequential has not been addressed …
H3K9 and H3K14 acetylation co-occur at many gene regulatory elements, while H3K14ac marks a subset of inactive inducible promoters in mouse embryonic stem …
Background Transcription regulation in pluripotent embryonic stem (ES) cells is a complex
process that involves multitude of regulatory layers, one of which is post-translational …
process that involves multitude of regulatory layers, one of which is post-translational …
Is H3K4me3 instructive for transcription activation?
Tri‐methylation of lysine 4 on histone H3 (H3K4me3) is a near‐universal chromatin
modification at the transcription start site of active genes in eukaryotes from yeast to man …
modification at the transcription start site of active genes in eukaryotes from yeast to man …
CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer
C Zhong, WJ Jiang, Y Yao, Z Li, Y Li, S Wang… - Nature …, 2024 - nature.com
Resistance to chemotherapy has been a major hurdle that limits therapeutic benefits for
many types of cancer. Here we systematically identify genetic drivers underlying …
many types of cancer. Here we systematically identify genetic drivers underlying …
Molecular complexes at euchromatin, heterochromatin and centromeric chromatin
O Morrison, J Thakur - International Journal of Molecular Sciences, 2021 - mdpi.com
Chromatin consists of a complex of DNA and histone proteins as its core components and
plays an important role in both packaging DNA and regulating DNA metabolic pathways …
plays an important role in both packaging DNA and regulating DNA metabolic pathways …
Chemical and biochemical perspectives of protein lysine methylation
M Luo - Chemical reviews, 2018 - ACS Publications
Protein lysine methylation is a distinct posttranslational modification that causes minimal
changes in the size and electrostatic status of lysine residues. Lysine methylation plays …
changes in the size and electrostatic status of lysine residues. Lysine methylation plays …