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Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities
Covering: 2010 to 2021 Organisms in nature have evolved into proficient synthetic chemists,
utilizing specialized enzymatic machinery to biosynthesize an inspiring diversity of …
utilizing specialized enzymatic machinery to biosynthesize an inspiring diversity of …
Phytostilbenes as agrochemicals: Biosynthesis, bioactivity, metabolic engineering and biotechnology
Covering: 1976 to 2020. Although constituting a limited chemical family, phytostilbenes
represent an emblematic group of molecules among natural compounds. Ever since their …
represent an emblematic group of molecules among natural compounds. Ever since their …
Biosynthetic gene clusters and the evolution of fungal chemodiversity
Covering: up to 2019 Fungi produce a remarkable diversity of secondary metabolites: small,
bioactive molecules not required for growth but which are essential to their ecological …
bioactive molecules not required for growth but which are essential to their ecological …
Till death do us pair: Co-evolution of plant–necrotroph interactions
Plants use programmed cell death as a potent defense response against biotrophic
pathogens that require living host cells to thrive. However, cell death can promote infection …
pathogens that require living host cells to thrive. However, cell death can promote infection …
[PDF][PDF] The architecture of metabolism maximizes biosynthetic diversity in the largest class of fungi
Ecological diversity in fungi is largely defined by metabolic traits, including the ability to
produce secondary or “specialized” metabolites (SMs) that mediate interactions with other …
produce secondary or “specialized” metabolites (SMs) that mediate interactions with other …
Endophyte genomes support greater metabolic gene cluster diversity compared with non-endophytes in Trichoderma
Trichoderma is a cosmopolitan genus with diverse lifestyles and nutritional modes, including
mycotrophy, saprophytism, and endophytism. Previous research has reported greater …
mycotrophy, saprophytism, and endophytism. Previous research has reported greater …
Metabolic gene clusters, fungal diversity, and the generation of accessory functions
Highlights•Many of life's adaptive accessory functions are encoded in metabolic gene
clusters.•Cluster evolution is intertwined with the processes generating accessory …
clusters.•Cluster evolution is intertwined with the processes generating accessory …
Ecological generalism drives hyperdiversity of secondary metabolite gene clusters in xylarialean endophytes
Although secondary metabolites are typically associated with competitive or pathogenic
interactions, the high bioactivity of endophytic fungi in the Xylariales, coupled with their …
interactions, the high bioactivity of endophytic fungi in the Xylariales, coupled with their …
Lower Funneling Pathways in Scedosporium Species
W Poirier, K Ravenel, JP Bouchara… - Frontiers in Microbiology, 2021 - frontiersin.org
Lignin, a natural polyaromatic macromolecule, represents an essential component of the
lignocellulose biomass. Due to its complexity, the natural degradation of this molecule by …
lignocellulose biomass. Due to its complexity, the natural degradation of this molecule by …
Phenolic degradation by catechol dioxygenases is associated with pathogenic fungi with a necrotrophic lifestyle in the Ceratocystidaceae
Fungal species of the Ceratocystidaceae grow on their host plants using a variety of different
lifestyles, from saprophytic to highly pathogenic. Although many genomes of fungi in the …
lifestyles, from saprophytic to highly pathogenic. Although many genomes of fungi in the …