Aldehyde dehydrogenase (ALDH) is a superfamily of enzymes that detoxify a variety of
endogenous and exogenous aldehydes and are required for the biosynthesis of retinoic …

The cancer stem cell (CSC) model defines tumors as hierarchically organized entities,
containing a small population of tumorigenic CSC, or tumour-initiating cells, placed at the …

Breast cancer is the most common cancer in women and a leading cause of cancer-related
deaths for women worldwide. Various cell models have been developed to study breast …

Although cancer stem cells have been well characterized in numerous malignancies, the
fundamental characteristics of this group of cells, however, have been challenged by some …

The cellular heterogeneity of breast cancers still represents a major therapeutic challenge.
The latest genomic studies have classified breast cancers in distinct clusters to inform the …

Breast cancer is the most frequent cancer in women worldwide and late diagnosis often
adversely affects the prognosis of the disease. Radiotherapy is commonly used to treat …

Tumors are heterogeneous and composed of cells with different dissemination abilities.
Despite significant effort, there is no universal biological marker that serves as a metric for …

Simple Summary Presently, the study of cancer stem cells is important because these cells
increase the cancer complexity, confer tumors the ability to grow, resist treatment, and …

Cancer is a multifaceted disease characterized by heterogeneous genetic alterations and
cellular metabolism, at the organ, tissue, and cellular level. Key features of cancer …

Acquisition of chemoresistance and metastatic phenotype are the major causes of breast
cancer treatment failure and cancer-related mortality. Recently, a plethora of experimental …