The complement cascade comprises soluble and cell surface proteins and is an important
arm of the innate immune system. Once activated, the complement system rapidly generates …

Introduction Neutrophil extracellular traps (NETs) are web-like structures composed of
nuclear and granular components. The primary role of NETS is to prevent the dissemination …

The development of complement inhibitors represented one of the major breakthroughs in
clinical nephrology in the last decade. Complement inhibition has dramatically transformed …

Drug repurposing in glomerular disease can deliver opportunities for steroid-free regimens,
enable personalized multi-target options for resistant or relapsing disease and enhance …

Background Several lines of evidence implicate that there are distinct differences between
patients with myeloperoxidase (MPO)-antineutrophil cytoplasmic antibody (ANCA) and anti …

Anti-glomerular basement membrane (GBM) disease is a rare but life-threatening
autoimmune disorder characterized by rapidly progressive glomerulonephritis with or …

The complement system is an ancient and phylogenetically conserved key danger sensing
system that is critical for host defense against pathogens. Activation of the complement …

Objective To explore the clinical characteristics of double-seropositive patients (DPPs) with
anti-glomerular basement membrane (Anti-GBM) antibodies and anti-neutrophil cytoplasmic …

Combination therapy with glucocorticoids, cyclophosphamide, and plasmapheresis is
recommended as the standard treatment for anti-glomerular basement membrane (anti …

Abstract Treatment of aggressive antineutrophil cytoplasmic antibody-associated Vasculitis
with Eculizumab. The role of the complement system in chronic inflammatory demyelinating …