The chemical identity of RNA molecules beyond the four standard ribonucleosides has
fascinated scientists since pseudouridine was characterized as the “fifth” ribonucleotide in …

The posttranscriptional modifications of tRNA's anticodon stem and loop (ASL) domain
represent a third level, a third code, to the accuracy and efficiency of translating mRNA …

N 4-Acetylcytidine (ac4C) is a post-transcriptional modification of RNA that is conserved
across all domains of life. All characterized sites of ac4C in eukaryotic RNA occur in the …

Post-transcriptional modifications to messenger RNAs (mRNAs) have the potential to alter
the biological function of this important class of biomolecules. The study of mRNA …

Cells use chemical modifications to alter the sterics, charge, and conformations of large
biomolecules, modulating their biogenesis, function, and stability. Until recently post …

Gastric cancer is a highly malignant tumor. Gastric cancer stem cells (GCSCs) are the main
causes of drug resistance, metastasis, recurrence, and poor prognosis. As a secondary …

Modified nucleobases are found in functionally important regions of RNA and are often
responsible for essential structural roles. Many of these nucleobase modifications are …

5-Formylcytidine (f5C) is one type of post-transcriptional RNA modification, which is known
at the wobble position of tRNA in mitochondria and essential for mitochondrial protein …

Liquid–liquid phase separation (LLPS), an emerging biophysical phenomenon, can
sequester molecules to implement physiological and pathological functions. LLPS …

The mechanism by which the recently identified DNA modification 5-formylcytosine (fC) is
recognized by epigenetic writer and reader proteins is not known. Recently, an unusual …