Triple negative breast cancer: A thorough review of biomarkers

JL da Silva, NCC Nunes, P Izetti… - Critical reviews in …, 2020 - Elsevier
Triple-negative breast cancer (TNBC) is defined as a type of breast cancer with lack of
expression of estrogen receptor (ER), progesterone receptor (PR) and HER2 protein. The …

Current triple-negative breast cancer subtypes: dissecting the most aggressive form of breast cancer

M Ensenyat-Mendez, P Llinàs-Arias, JIJ Orozco… - Frontiers in …, 2021 - frontiersin.org
Triple-negative breast cancer (TNBC) is a highly heterogeneous disease defined by the
absence of estrogen receptor (ER) and progesterone receptor (PR) expression, and human …

MethSurv: a web tool to perform multivariable survival analysis using DNA methylation data

V Modhukur, T Iljasenko, T Metsalu, K Lokk… - …, 2018 - Taylor & Francis
Aim: To develop a web tool for survival analysis based on CpG methylation patterns.
Materials & methods: We utilized methylome data from 'The Cancer Genome Atlas' and used …

Biology and management of patients with triple-negative breast cancer

P Sharma - The oncologist, 2016 - academic.oup.com
Triple-negative breast cancer (TNBC) accounts for 15% of all breast cancers and is
associated with poor long-term outcomes compared with other breast cancer subtypes …

Cancer epigenetics: Moving forward

A Nebbioso, FP Tambaro, C Dell'Aversana… - PLoS genetics, 2018 - journals.plos.org
Defects in chromatin modifiers and remodelers have been described both for hematological
and solid malignancies, corroborating and strengthening the role of epigenetic aberrations …

Nanoparticles-based drug delivery and gene therapy for breast cancer: Recent advancements and future challenges

Z Mirza, S Karim - Seminars in cancer biology, 2021 - Elsevier
Breast cancer (BC) is amongst the most lethal cancer among females and conventional
treatment methods like surgery, radiotherapy and chemotherapy are not effective enough as …

Single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity

SJ Clark, HJ Lee, SA Smallwood, G Kelsey, W Reik - Genome biology, 2016 - Springer
Emerging single-cell epigenomic methods are being developed with the exciting potential to
transform our knowledge of gene regulation. Here we review available techniques and …

Epigenetics of breast cancer: Biology and clinical implication in the era of precision medicine

B Pasculli, R Barbano, P Parrella - Seminars in cancer biology, 2018 - Elsevier
In the last years, mortality from breast cancer has declined in western countries as a
consequence of a more widespread screening resulting in earlier detection, as well as an …

Integrating multi-omics data through deep learning for accurate cancer prognosis prediction

H Chai, X Zhou, Z Zhang, J Rao, H Zhao… - Computers in biology and …, 2021 - Elsevier
Background Genomic information is nowadays widely used for precise cancer treatments.
Since the individual type of omics data only represents a single view that suffers from data …

DNA methylation biomarkers for noninvasive detection of triple‐negative breast cancer using liquid biopsy

M Manoochehri, N Borhani… - … Journal of Cancer, 2023 - Wiley Online Library
Noninvasive detection of aberrant DNA methylation could provide invaluable biomarkers for
earlier detection of triple‐negative breast cancer (TNBC) which could help clinicians with …