Background The growing body of evidence indicating the heterogeneity of Alzheimer's
disease (AD), coupled with disappointing clinical studies directed at a fit-for-all therapy …

Docosahexaenoic acid (DHA), a polyunsaturated fatty acid (PUFA) enriched in
phospholipids in the brain and retina, is known to play multi-functional roles in brain health …

Brain pathology of Alzheimer's diseases (AD) and the genetics of autosomal dominant
familial AD have been the “lamp posts” under which the AD field has been looking for …

The vast majority of Alzheimer's disease (AD) cases are late onset (LOAD), which is
genetically complex with heritability estimates up to 80%. Apolipoprotein E (APOE) has been …

Dietary interventions have emerged as effective environmental inducers of brain plasticity.
Among these dietary interventions, we here highlight the impact of caloric restriction (CR: a …

Importance The apolipoprotein E ε4 (APOE4) allele identifies a unique population that is at
significant risk for develo** Alzheimer disease (AD). Docosahexaenoic acid (DHA) is an …

Alzheimer disease (AD) is becoming one of the most prevalent neurodegenerative
conditions worldwide. Although the disease progression is becoming better understood …

Abstract Apolipoprotein E ε4 (APOE4) is the primary genetic risk factor for the late-onset form
of Alzheimer's disease (AD). Although the reason for this association is not completely …

Importance Seafood consumption is promoted for its many health benefits even though its
contamination by mercury, a known neurotoxin, is a growing concern. Objective To …

APOE-4 is the strongest genetic risk factor for Alzheimer's disease (AD), and is associated
with an increase in the levels of amyloid deposition and an early age of onset. Recent data …