Harnessing genomic information for livestock improvement

M Georges, C Charlier, B Hayes - Nature Reviews Genetics, 2019 - nature.com
The world demand for animal-based food products is anticipated to increase by 70% by
2050. Meeting this demand in a way that has a minimal impact on the environment will …

1000 bull genomes project to map simple and complex genetic traits in cattle: applications and outcomes

BJ Hayes, HD Daetwyler - Annual review of animal biosciences, 2019 - annualreviews.org
The 1000 Bull Genomes Project is a collection of whole-genome sequences from 2,703
individuals capturing a significant proportion of the world's cattle diversity. So far, 84 million …

Ancestry-inclusive dog genomics challenges popular breed stereotypes

K Morrill, J Hekman, X Li, J McClure, B Logan… - Science, 2022 - science.org
Behavioral genetics in dogs has focused on modern breeds, which are isolated subgroups
with distinctive physical and, purportedly, behavioral characteristics. We interrogated breed …

Whole genome sequencing of canids reveals genomic regions under selection and variants influencing morphology

J Plassais, J Kim, BW Davis, DM Karyadi… - Nature …, 2019 - nature.com
Domestic dog breeds are characterized by an unrivaled diversity of morphologic traits and
breed-associated behaviors resulting from human selective pressures. To identify the …

[PDF][PDF] Whole-genome resequencing of worldwide wild and domestic sheep elucidates genetic diversity, introgression, and agronomically important loci

FH Lv, YH Cao, GJ Liu, LY Luo, R Lu… - Molecular biology …, 2022 - academic.oup.com
Domestic sheep and their wild relatives harbor substantial genetic variants that can form the
backbone of molecular breeding, but their genome landscapes remain understudied. Here …

A large-scale genome-wide association study in US Holstein cattle

J Jiang, L Ma, D Prakapenka, PM VanRaden… - Frontiers in …, 2019 - frontiersin.org
Genome-wide association study (GWAS) is a powerful approach to identify genomic regions
and genetic variants associated with phenotypes. However, only limited mutual confirmation …

Conservation, acquisition, and functional impact of sex-biased gene expression in mammals

S Naqvi, AK Godfrey, JF Hughes, ML Goodheart… - Science, 2019 - science.org
INTRODUCTION Sex differences are widespread in humans and other mammals. For
example, the distribution of height or body size is shifted upwards in males relative to …

Meta-analysis of genome-wide association studies provides insights into genetic control of tomato flavor

J Zhao, C Sauvage, J Zhao, F Bitton, G Bauchet… - Nature …, 2019 - nature.com
Tomato flavor has changed over the course of long-term domestication and intensive
breeding. To understand the genetic control of flavor, we report the meta-analysis of genome …

Functional annotation of animal genomes (FAANG): current achievements and roadmap

E Giuffra, CK Tuggle… - Annual review of animal …, 2019 - annualreviews.org
Functional annotation of genomes is a prerequisite for contemporary basic and applied
genomic research, yet farmed animal genomics is deficient in such annotation. To address …

Genome-wide fine-map** identifies pleiotropic and functional variants that predict many traits across global cattle populations

R **ang, IM MacLeod, HD Daetwyler, G de Jong… - Nature …, 2021 - nature.com
The difficulty in finding causative mutations has hampered their use in genomic prediction.
Here, we present a methodology to fine-map potentially causal variants genome-wide by …