Glucagon-like peptide-1 and the central/peripheral nervous system: crosstalk in diabetes

G Muscogiuri, RA DeFronzo, A Gastaldelli… - Trends in Endocrinology …, 2017‏ - cell.com
Glucagon-like peptide-1 (GLP-1) is released in response to meals and exerts important roles
in the maintenance of normal glucose homeostasis. GLP-1 is also important in the regulation …

Comprehensive Management of stroke: From mechanisms to therapeutic approaches

A Arnalich-Montiel, A Burgos-Santamaría… - International Journal of …, 2024‏ - mdpi.com
Acute ischemic stroke (AIS) is a challenging disease, which needs urgent comprehensive
management. Endovascular thrombectomy (EVT), alone or combined with iv thrombolysis, is …

Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 …

L Liu, Q Cao, W Gao, B Li, Z **a, B Zhao - Aging (Albany NY), 2021‏ - pmc.ncbi.nlm.nih.gov
Diabetic patients are more vulnerable to cerebral ischemia-reperfusion (CIR) injury and
have a worse prognosis and higher mortality after ischemic stroke than non-diabetic …

Glycosylated hemoglobin and functional outcome after acute ischemic stroke

S Lattanzi, M Bartolini, L Provinciali… - Journal of Stroke and …, 2016‏ - Elsevier
Background Diabetes mellitus (DM) is associated to an increased incidence of cerebral and
myocardial infarction which could be reduced by long-term maintenance of optimal glycemic …

[HTML][HTML] Fluctuations in glucose levels induce glial toxicity with glutamatergic, oxidative and inflammatory implications

A Quincozes-Santos, LD Bobermin, AM de Assis… - … et Biophysica Acta (BBA …, 2017‏ - Elsevier
Astrocytes are dynamic cells that maintain brain homeostasis by regulating neurotransmitter
systems, antioxidant defenses, inflammatory responses and energy metabolism. Astroglial …

[HTML][HTML] Brain energy metabolism in ischemic stroke: effects of smoking and diabetes

AE Sifat, S Nozohouri, SR Archie… - International Journal of …, 2022‏ - mdpi.com
Proper regulation of energy metabolism in the brain is crucial for maintaining brain activity in
physiological and different pathophysiological conditions. Ischemic stroke has a complex …

Lycium barbarum polysaccharides decrease hyperglycemia-aggravated ischemic brain injury through maintaining mitochondrial fission and fusion balance

WJ Liu, HF Jiang, FUL Rehman… - … journal of biological …, 2017‏ - pmc.ncbi.nlm.nih.gov
Although it has been reported that polysaccharides found in Lycium barbarum possess
neuroprotective effects, little is known of their ability to ameliorate hyperglycemia-aggravated …

Chikusetsu saponin IVa ameliorates cerebral ischemia reperfusion injury in diabetic mice via adiponectin-mediated AMPK/GSK-3β pathway in vivo and in vitro

J Duan, Y Yin, J Cui, J Yan, Y Zhu, Y Guan, G Wei… - Molecular …, 2016‏ - Springer
Diabetes mellitus substantially increases the risk of stroke and enhances brain's
vulnerability to ischemia insult. In a previous study, Chikusetsu saponin IVa (CHS) …

Glycemic variability and acute ischemic stroke: the missing link?

EI González-Moreno, CR Cámara-Lemarroy… - Translational stroke …, 2014‏ - Springer
Hyperglycemia is commonly encountered in both diabetic and non-diabetic patients in acute
ischemic stroke. Hyperglycemia in stroke has been associated with poor clinical outcome, a …

Coenzyme Q10 ameliorates cerebral ischemia reperfusion injury in hyperglycemic rats

CJ Lu, YZ Guo, Y Zhang, L Yang, Y Chang… - … -Research and Practice, 2017‏ - Elsevier
The purpose of this study is to investigate the effect of coenzyme Q10 (CoQ10) on focal
cerebral ischemia/reperfusion (I/R) injury in hyperglycemic rats and the possible involved …