Secretory proteins are conventionally transported through the endoplasmic reticulum to the
Golgi and then to the plasma membrane where they are released into the extracellular …

Most secretory proteins travel through a well-documented conventional secretion pathway
involving the endoplasmic reticulum (ER) and the Golgi complex. However, recently, it has …

Cortical organoids are self-organizing three-dimensional cultures that model features of the
develo** human cerebral cortex,. However, the fidelity of organoid models remains …

Interactions between angiogenesis and neurogenesis regulate embryonic brain
development. However, a comprehensive understanding of the stages of vascular cell …

Nuclear protein HMGB1 is secreted in response to various stimuli and functions as a danger-
associated molecular pattern. Extracellular HMGB1 induces inflammation, cytokine …

CFTR biogenesis starts with its co-translational insertion into the membrane of endoplasmic
reticulum and folding of the cytosolic domains, towards the acquisition of a fully folded …

Cells communicate with their environment via surface proteins and secreted factors.
Unconventional protein secretion (UPS) is an evolutionarily conserved process, via which …

This comprehensive review article dives deep into the Golgi apparatus, an essential
organelle in cellular biology. Beginning with its discovery during the 19th century until …

It has been demonstrated that two Golgi stacking proteins, GRASP55 and GRASP65, self-
interact to form trans-oligomers that tether adjacent Golgi membranes into stacks and …

The Golgi complex is the membrane-bound organelle that lies at the center of the secretory
pathway. Its main functions are to maintain cellular lipid homeostasis, to orchestrate protein …