Interferons (IFNs), which were discovered a half century ago, are a group of secreted
proteins that play key roles in innate immunity against viral infection. The major signaling …

Zika virus (ZIKV) remained largely quiescent for nearly six decades after its first appearance
in 1947. ZIKV reappeared after 2007, resulting in a declaration of an international “public …

The antiviral innate immunity is the first line of host defense against virus infections. In
mammalian cells, viral infections initiate the expression of interferons (IFNs) in the host that …

Highlights•Recent advances in Zika virus drug discovery efforts.•Drug repositioning and
computationally guided compounds.•New inhibitors and promising ZIKV molecular …

Zika virus (ZIKV) infection and pathogenesis are linked to the disruption of neurogenesis,
congenital Zika syndrome and microcephaly by affecting neural progenitor cells …

Flaviviruses, including dengue (DENV), Zika (ZIKV), West Nile (WNV), Japanese
encephalitis (JEV), yellow fever (YFV), and tick-borne encephalitis (TBEV) viruses, pose a …

While Zika virus (ZIKV) circulated for decades (African lineage strains) without report of
outbreaks and severe complications, its emergence in French Polynesia and subsequently …

Protein–protein interactions (PPIs) are responsible for a number of key physiological
processes in the living cells and underlie the pathomechanism of many diseases …

The identification of four potential nonstructural 5 (NS5) residues—K28, K45, V335, and
S749—that share the same amino acid preference in STAT2-interacting flaviviruses …

During recent Zika epidemics, adults infected with Zika virus (ZIKV) have developed organ-
specific inflammatory complications. The most serious Zika-associated inflammatory eye …