The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy

HH Han, HM Wang, P Jangili, M Li, L Wu… - Chemical Society …, 2023 - pubs.rsc.org
Cancer remains as one of the most significant health problems, with approximately 19
million people diagnosed worldwide each year. Chemotherapy is a routinely used method to …

Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy

TC Pham, VN Nguyen, Y Choi, S Lee, J Yoon - Chemical reviews, 2021 - ACS Publications
This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

The fast-growing field of photo-driven theranostics based on aggregation-induced emission

Z Zhang, M Kang, H Tan, N Song, M Li, P **ao… - Chemical Society …, 2022 - pubs.rsc.org
Photo-driven theranostics, also known as phototheranostics, relying on the diverse excited-
state energy conversions of theranostic agents upon photoexcitation represents a significant …

Activatable nano-photosensitizers for precise photodynamic cancer therapy

Z Li, Z Zhou, Y Wang, J Wang, L Zhou… - Coordination Chemistry …, 2023 - Elsevier
Owing to the excellent cell ablation ability and low side effects, photodynamic therapy (PDT)
plays an important role in disease treatment, especially cancer. However, most PDT agents …

Acceptor Planarization and Donor Rotation: A Facile Strategy for Realizing Synergistic Cancer Phototherapy via Type I PDT and PTT

L Feng, C Li, L Liu, Z Wang, Z Chen, J Yu, W Ji… - ACS …, 2022 - ACS Publications
Tumor hypoxia seriously impairs the therapeutic outcomes of type II photodynamic therapy
(PDT), which is highly dependent upon tissue oxygen concentration. Herein, a facile strategy …

Designing bioresponsive nanomaterials for intracellular self-assembly

S Chagri, DYW Ng, T Weil - Nature Reviews Chemistry, 2022 - nature.com
Supramolecular assemblies are essential components of living organisms. Cellular
scaffolds, such as the cytoskeleton or the cell membrane, are formed via secondary …

Recent advances of AIE light-up probes for photodynamic therapy

S Liu, G Feng, BZ Tang, B Liu - Chemical science, 2021 - pubs.rsc.org
As a new non-invasive treatment method, photodynamic therapy (PDT) has attracted great
attention in biomedical applications. The advantages of possessing fluorescence for …

Aggregation‐enhanced theranostics: AIE sparkles in biomedical field

M Kang, Z Zhang, N Song, M Li, P Sun, X Chen… - …, 2020 - Wiley Online Library
Theranostics referring to the ingenious integration of diagnostics and therapeutics has
garnered tremendous attention in these years as it provides a promising opportunity for …

Aggregation‐induced emission: recent advances in materials and biomedical applications

X Cai, B Liu - Angewandte Chemie International Edition, 2020 - Wiley Online Library
The concept of aggregation‐induced emission (AIE) has opened new opportunities in many
research fields. Motivated by the unique feature of AIE fluorogens (AIEgens), during the past …

Stimuli‐responsive manganese single‐atom nanozyme for tumor therapy via integrated cascade reactions

Y Zhu, W Wang, J Cheng, Y Qu, Y Dai… - Angewandte …, 2021 - Wiley Online Library
The single‐atom enzyme (SAE) is a novel type of nanozyme that exhibits extraordinary
catalytic activity. Here, we constructed a PEGylated manganese‐based SAE (Mn/PSAE) by …