[HTML][HTML] Circadian rhythm of cardiac electrophysiology, arrhythmogenesis, and the underlying mechanisms

N Black, A D'Souza, Y Wang, H Piggins, H Dobrzynski… - Heart rhythm, 2019 - Elsevier
Cardiac arrhythmias are a leading cause of cardiovascular death. It has long been accepted
that life-threatening cardiac arrhythmias (ventricular tachycardia, ventricular fibrillation, and …

Translational challenges in atrial fibrillation

J Heijman, JB Guichard, D Dobrev, S Nattel - Circulation research, 2018 - ahajournals.org
Atrial fibrillation (AF) is the most common sustained heart rhythm disorder and is associated
with substantial morbidity and mortality. Current treatment options for AF have significant …

Sleep fragmentation exacerbates myocardial ischemia‒reperfusion injury by promoting copper overload in cardiomyocytes

N Chen, L Guo, L Wang, S Dai, X Zhu… - Nature communications, 2024 - nature.com
Sleep disorders increase the risk and mortality of heart disease, but the brain-heart
interaction has not yet been fully elucidated. Cuproptosis is a copper-dependent type of cell …

[HTML][HTML] Insight into the role of the PI3K/Akt pathway in ischemic injury and post-infarct left ventricular remodeling in normal and diabetic heart

B Walkowski, M Kleibert, M Majka, M Wojciechowska - Cells, 2022 - mdpi.com
Despite the significant decline in mortality, cardiovascular diseases are still the leading
cause of death worldwide. Among them, myocardial infarction (MI) seems to be the most …

[HTML][HTML] Ventricular arrhythmias in ischemic cardiomyopathy—new avenues for mechanism-guided treatment

M Amoni, E Dries, S Ingelaere, D Vermoortele… - Cells, 2021 - mdpi.com
Ischemic heart disease is the most common cause of lethal ventricular arrhythmias and
sudden cardiac death (SCD). In patients who are at high risk after myocardial infarction …

Molecular and cellular neurocardiology: development, and cellular and molecular adaptations to heart disease

BA Habecker, ME Anderson, SJ Birren… - The Journal of …, 2016 - Wiley Online Library
The nervous system and cardiovascular system develop in concert and are functionally
interconnected in both health and disease. This white paper focuses on the cellular and …

Mechanism of ventricular tachycardia occurring in chronic myocardial infarction scar

JK Donahue, J Chrispin, OA Ajijola - Circulation research, 2024 - ahajournals.org
Cardiac arrest is the leading cause of death in the more economically developed countries.
Ventricular tachycardia associated with myocardial infarct is a prominent cause of cardiac …

[HTML][HTML] Stellate ganglia and cardiac sympathetic overactivation in heart failure

YL Li - International journal of molecular sciences, 2022 - mdpi.com
Heart failure (HF) is a major public health problem worldwide, especially coronary heart
disease (myocardial infarction)-induced HF with reduced ejection fraction (HFrEF), which …

Preclinical models of myocardial infarction: from mechanism to translation

TP Martin, EA MacDonald… - British Journal of …, 2022 - Wiley Online Library
Approximately 7 million people are affected by acute myocardial infarction (MI) each year,
and despite significant therapeutic and diagnostic advancements, MI remains a leading …

Molecular and cellular neurocardiology in heart disease

BA Habecker, DM Bers, SJ Birren… - The Journal of …, 2024 - Wiley Online Library
This paper updates and builds on a previous White Paper in this journal that some of us
contributed to concerning the molecular and cellular basis of cardiac neurobiology of heart …