Tissue damaging toxins in snake venoms: mechanisms of action, pathophysiology and treatment strategies

MA Bittenbinder, J van Thiel, FC Cardoso… - Communications …, 2024 - nature.com
Snakebite envenoming is an important public health issue responsible for mortality and
severe morbidity. Where mortality is mainly caused by venom toxins that induce …

Snakebite envenoming diagnosis and diagnostics

C Knudsen, JA Jürgensen, S Føns, AM Haack… - Frontiers in …, 2021 - frontiersin.org
Snakebite envenoming is predominantly an occupational disease of the rural tropics,
causing death or permanent disability to hundreds of thousands of victims annually. The …

[HTML][HTML] Varespladib in the treatment of snakebite envenoming: development history and preclinical evidence supporting advancement to clinical trials in patients …

MR Lewin, RW Carter, IA Matteo, SP Samuel, S Rao… - Toxins, 2022 - mdpi.com
The availability of effective, reliably accessible, and affordable treatments for snakebite
envenoming is a critical and long unmet medical need. Recently, small, synthetic toxin …

[HTML][HTML] The search for natural and synthetic inhibitors that would complement antivenoms as therapeutics for snakebite envenoming

JM Gutiérrez, LO Albulescu, RH Clare, NR Casewell… - Toxins, 2021 - mdpi.com
A global strategy, under the coordination of the World Health Organization, is being unfolded
to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure …

[HTML][HTML] Old World Vipers—a review about snake venom proteomics of Viperinae and their variations

M Damm, BF Hempel, RD Süssmuth - Toxins, 2021 - mdpi.com
Fine-tuned by millions of years of evolution, snake venoms have frightened but also
fascinated humanity and nowadays they constitute potential resources for drug …

Progress and challenges in the field of snakebite envenoming therapeutics

JM Gutiérrez, N R. Casewell… - Annual Review of …, 2024 - annualreviews.org
Snakebite envenoming kills and maims hundreds of thousands of people every year,
especially in the rural settings of tropical regions. Envenomings are still treated with animal …

Plant-derived toxin inhibitors as potential candidates to complement antivenom treatment in snakebite envenomations

AAX Adrião, AO Dos Santos, EJSP de Lima… - Frontiers in …, 2022 - frontiersin.org
Snakebite envenomations (SBEs) are a neglected medical condition of global importance
that mainly affect the tropical and subtropical regions. Clinical manifestations include pain …

[HTML][HTML] Clinical management of snakebite envenoming: future perspectives

M Hamza, C Knudsen, CA Gnanathasan, W Monteiro… - Toxicon: X, 2021 - Elsevier
Snakebite envenoming is a major cause of morbidity and mortality in rural communities
throughout the tropics. Generally, the main clinical features of snakebites are local swelling …

[HTML][HTML] Towards better antivenoms: navigating the road to new types of snakebite envenoming therapies

S Thumtecho, NJ Burlet, A Ljungars… - Journal of Venomous …, 2023 - SciELO Brasil
Snakebite envenoming is a significant global health challenge, and for over a century,
traditional plasma-derived antivenoms from hyperimmunized animals have been the primary …

[HTML][HTML] A review of the proteomic profiling of African Viperidae and Elapidae snake venoms and their antivenom neutralisation

BC Offor, B Muller, LA Piater - Toxins, 2022 - mdpi.com
Snakebite envenoming is a neglected tropical disease (NTD) that results from the injection
of snake venom of a venomous snake into animals and humans. In Africa (mainly in sub …