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Tissue damaging toxins in snake venoms: mechanisms of action, pathophysiology and treatment strategies
Snakebite envenoming is an important public health issue responsible for mortality and
severe morbidity. Where mortality is mainly caused by venom toxins that induce …
severe morbidity. Where mortality is mainly caused by venom toxins that induce …
Snakebite envenoming diagnosis and diagnostics
Snakebite envenoming is predominantly an occupational disease of the rural tropics,
causing death or permanent disability to hundreds of thousands of victims annually. The …
causing death or permanent disability to hundreds of thousands of victims annually. The …
[HTML][HTML] Varespladib in the treatment of snakebite envenoming: development history and preclinical evidence supporting advancement to clinical trials in patients …
MR Lewin, RW Carter, IA Matteo, SP Samuel, S Rao… - Toxins, 2022 - mdpi.com
The availability of effective, reliably accessible, and affordable treatments for snakebite
envenoming is a critical and long unmet medical need. Recently, small, synthetic toxin …
envenoming is a critical and long unmet medical need. Recently, small, synthetic toxin …
[HTML][HTML] The search for natural and synthetic inhibitors that would complement antivenoms as therapeutics for snakebite envenoming
A global strategy, under the coordination of the World Health Organization, is being unfolded
to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure …
to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure …
[HTML][HTML] Old World Vipers—a review about snake venom proteomics of Viperinae and their variations
Fine-tuned by millions of years of evolution, snake venoms have frightened but also
fascinated humanity and nowadays they constitute potential resources for drug …
fascinated humanity and nowadays they constitute potential resources for drug …
Progress and challenges in the field of snakebite envenoming therapeutics
JM Gutiérrez, N R. Casewell… - Annual Review of …, 2024 - annualreviews.org
Snakebite envenoming kills and maims hundreds of thousands of people every year,
especially in the rural settings of tropical regions. Envenomings are still treated with animal …
especially in the rural settings of tropical regions. Envenomings are still treated with animal …
Plant-derived toxin inhibitors as potential candidates to complement antivenom treatment in snakebite envenomations
AAX Adrião, AO Dos Santos, EJSP de Lima… - Frontiers in …, 2022 - frontiersin.org
Snakebite envenomations (SBEs) are a neglected medical condition of global importance
that mainly affect the tropical and subtropical regions. Clinical manifestations include pain …
that mainly affect the tropical and subtropical regions. Clinical manifestations include pain …
[HTML][HTML] Clinical management of snakebite envenoming: future perspectives
Snakebite envenoming is a major cause of morbidity and mortality in rural communities
throughout the tropics. Generally, the main clinical features of snakebites are local swelling …
throughout the tropics. Generally, the main clinical features of snakebites are local swelling …
[HTML][HTML] Towards better antivenoms: navigating the road to new types of snakebite envenoming therapies
Snakebite envenoming is a significant global health challenge, and for over a century,
traditional plasma-derived antivenoms from hyperimmunized animals have been the primary …
traditional plasma-derived antivenoms from hyperimmunized animals have been the primary …
[HTML][HTML] A review of the proteomic profiling of African Viperidae and Elapidae snake venoms and their antivenom neutralisation
Snakebite envenoming is a neglected tropical disease (NTD) that results from the injection
of snake venom of a venomous snake into animals and humans. In Africa (mainly in sub …
of snake venom of a venomous snake into animals and humans. In Africa (mainly in sub …