The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

▪ Abstract Nerve regeneration is a complex biological phenomenon. In the peripheral
nervous system, nerves can regenerate on their own if injuries are small. Larger injuries …

▪ Abstract Nerve growth factor (NGF) was discovered 50 years ago as a molecule that
promoted the survival and differentiation of sensory and sympathetic neurons. Its roles in …

Functional recovery from peripheral nerve injury and repair depends on a multitude of
factors, both intrinsic and extrinsic to neurons. Neuronal survival after axotomy is a …

During the past two decades, an important focus of pain research has been the study of
chronic pain mechanisms, particularly the processes that lead to the abnormal sensitivity …

For many decades, the inability of lesioned central neurons to regrow was accepted almost
as a" law of nature", and on the clinical level, spinal cord and brain lesions were seen as …

In this review, we first provide a brief historical perspective, discussing how peripheral nerve
injury (PNI) may have caused World War I. We then consider the initiation, progression, and …

Whereas the central nervous system (CNS) usually cannot regenerate, peripheral nerves
regenerate spontaneously after injury because of a permissive environment and activation …

Surgical repair of severe peripheral nerve injuries represents not only a pressing medical
need, but also a great clinical challenge. Autologous nerve grafting remains a golden …

In spite of an enormous amount of new experimental laboratory data based on evolving
neuroscientific concepts during the last 25 years peripheral nerve injuries still belong to the …