The molecular mechanisms of glucocorticoids-mediated neutrophil survival

AS Saffar, H Ashdown, AS Gounni - Current drug targets, 2011 - ingentaconnect.com
Neutrophil-dominated inflammation plays an important role in many airway diseases
including asthma, chronic obstructive pulmonary disease (COPD), bronchiolitis and cystic …

Ellagic acid, phenolic acids, and flavonoids in Malaysian honey extracts demonstrate in vitro anti-inflammatory activity

M Kassim, M Achoui, MR Mustafa, MA Mohd, KM Yusoff - Nutrition research, 2010 - Elsevier
Natural honey has been used in traditional medicine of different cultures throughout the
world. This study looked into the extraction of Malaysian honey and the evaluation of the anti …

IGF-1 facilitates cartilage reconstruction by regulating PI3K/AKT, MAPK, and NF-kB signaling in rabbit osteoarthritis

MA Hossain, A Adithan, MJ Alam… - Journal of …, 2021 - Taylor & Francis
Purpose The pathogenesis of osteoarthritis (OA) is characterized by joint degeneration. The
pro-inflammatory cytokine interleukin (IL)-1β plays a vital role in the pathogenesis of OA by …

Ginsenoside-Rb1 prevents bone cartilage destruction through down-regulation of p-Akt, p-P38, and p-P65 signaling in rabbit

MA Hossain, MJ Alam, B Kim, CW Kang, JH Kim - Phytomedicine, 2022 - Elsevier
Background Osteoarthritis (OA) is the most common joint complaint resulting in pain,
disability, and loss of quality of life. On the other hand, ginsenoside-Rb1 is a plant product …

Modulation of early human preadipocyte differentiation by glucocorticoids

JJ Tomlinson, A Boudreau, D Wu, E Atlas… - …, 2006 - academic.oup.com
Glucocorticoids provide an adipogenic stimulus that is most obvious in the truncal obesity of
patients with Cushing's syndrome. Glucocorticoid treatment also strongly potentiates the …

Dexamethasone protects organ of corti explants against tumor necrosis factor-alpha–induced loss of auditory hair cells and alters the expression levels of apoptosis …

CT Dinh, S Haake, S Chen, K Hoang, E Nong… - Neuroscience, 2008 - Elsevier
Objective: Determine the molecular mechanism (s) behind tumor necrosis factor-alpha
(TNFα)–induced loss of auditory hair cells and the ability of dexamethasone base (DXMb) to …

A noncanonical NF-κB pathway through the p50 subunit regulates Bcl-2 overexpression during an oxidative-conditioning hormesis response

A Luna-López, VY González-Puertos… - Free Radical Biology …, 2013 - Elsevier
Cells can respond to damage and stress by activating various repair and survival pathways.
One of these responses can be induced by preconditioning the cells with sublethal stress to …

Phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase regulate induction of Mcl-1 and survival in glucocorticoid-treated human neutrophils

AS Saffar, S Dragon, P Ezzati, L Shan… - Journal of allergy and …, 2008 - Elsevier
BACKGROUND: Glucocorticoids have been shown to inhibit human neutrophil apoptosis,
with implications that this might help accentuate neutrophilic inflammation. OBJECTIVE: The …

BDNF protects human vascular endothelial cells from TNFα-induced apoptosis

K Takeda, P Kermani, A Anastasia… - … and Cell Biology, 2013 - cdnsciencepub.com
Brain-derived neurotrophic factor (BDNF) enhances periodontal tissue regeneration. Tissue
regeneration is characterized by inflammation that directs the quality of tissue repair. In this …

Bcl-2 sustains hormetic response by inducing Nrf-2 nuclear translocation in L929 mouse fibroblasts

A Luna-López, F Triana-Martínez… - Free radical biology and …, 2010 - Elsevier
Hormesis is the process whereby exposure to a low dose of a chemical agent induces an
adaptive effect on the cell or organism. This response evokes the expression of …