The molecular mechanisms of glucocorticoids-mediated neutrophil survival
AS Saffar, H Ashdown, AS Gounni - Current drug targets, 2011 - ingentaconnect.com
Neutrophil-dominated inflammation plays an important role in many airway diseases
including asthma, chronic obstructive pulmonary disease (COPD), bronchiolitis and cystic …
including asthma, chronic obstructive pulmonary disease (COPD), bronchiolitis and cystic …
Ellagic acid, phenolic acids, and flavonoids in Malaysian honey extracts demonstrate in vitro anti-inflammatory activity
Natural honey has been used in traditional medicine of different cultures throughout the
world. This study looked into the extraction of Malaysian honey and the evaluation of the anti …
world. This study looked into the extraction of Malaysian honey and the evaluation of the anti …
IGF-1 facilitates cartilage reconstruction by regulating PI3K/AKT, MAPK, and NF-kB signaling in rabbit osteoarthritis
Purpose The pathogenesis of osteoarthritis (OA) is characterized by joint degeneration. The
pro-inflammatory cytokine interleukin (IL)-1β plays a vital role in the pathogenesis of OA by …
pro-inflammatory cytokine interleukin (IL)-1β plays a vital role in the pathogenesis of OA by …
Ginsenoside-Rb1 prevents bone cartilage destruction through down-regulation of p-Akt, p-P38, and p-P65 signaling in rabbit
MA Hossain, MJ Alam, B Kim, CW Kang, JH Kim - Phytomedicine, 2022 - Elsevier
Background Osteoarthritis (OA) is the most common joint complaint resulting in pain,
disability, and loss of quality of life. On the other hand, ginsenoside-Rb1 is a plant product …
disability, and loss of quality of life. On the other hand, ginsenoside-Rb1 is a plant product …
Modulation of early human preadipocyte differentiation by glucocorticoids
JJ Tomlinson, A Boudreau, D Wu, E Atlas… - …, 2006 - academic.oup.com
Glucocorticoids provide an adipogenic stimulus that is most obvious in the truncal obesity of
patients with Cushing's syndrome. Glucocorticoid treatment also strongly potentiates the …
patients with Cushing's syndrome. Glucocorticoid treatment also strongly potentiates the …
Dexamethasone protects organ of corti explants against tumor necrosis factor-alpha–induced loss of auditory hair cells and alters the expression levels of apoptosis …
Objective: Determine the molecular mechanism (s) behind tumor necrosis factor-alpha
(TNFα)–induced loss of auditory hair cells and the ability of dexamethasone base (DXMb) to …
(TNFα)–induced loss of auditory hair cells and the ability of dexamethasone base (DXMb) to …
A noncanonical NF-κB pathway through the p50 subunit regulates Bcl-2 overexpression during an oxidative-conditioning hormesis response
A Luna-López, VY González-Puertos… - Free Radical Biology …, 2013 - Elsevier
Cells can respond to damage and stress by activating various repair and survival pathways.
One of these responses can be induced by preconditioning the cells with sublethal stress to …
One of these responses can be induced by preconditioning the cells with sublethal stress to …
Phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase regulate induction of Mcl-1 and survival in glucocorticoid-treated human neutrophils
AS Saffar, S Dragon, P Ezzati, L Shan… - Journal of allergy and …, 2008 - Elsevier
BACKGROUND: Glucocorticoids have been shown to inhibit human neutrophil apoptosis,
with implications that this might help accentuate neutrophilic inflammation. OBJECTIVE: The …
with implications that this might help accentuate neutrophilic inflammation. OBJECTIVE: The …
BDNF protects human vascular endothelial cells from TNFα-induced apoptosis
K Takeda, P Kermani, A Anastasia… - … and Cell Biology, 2013 - cdnsciencepub.com
Brain-derived neurotrophic factor (BDNF) enhances periodontal tissue regeneration. Tissue
regeneration is characterized by inflammation that directs the quality of tissue repair. In this …
regeneration is characterized by inflammation that directs the quality of tissue repair. In this …
Bcl-2 sustains hormetic response by inducing Nrf-2 nuclear translocation in L929 mouse fibroblasts
Hormesis is the process whereby exposure to a low dose of a chemical agent induces an
adaptive effect on the cell or organism. This response evokes the expression of …
adaptive effect on the cell or organism. This response evokes the expression of …