The tumor microenvironment: a milieu hindering and obstructing antitumor immune responses

A Labani-Motlagh, M Ashja-Mahdavi… - Frontiers in …, 2020 - frontiersin.org
The success of cancer immunotherapy relies on the knowledge of the tumor
microenvironment and the immune evasion mechanisms in which the tumor, stroma, and …

Exosome-based immunotherapy: a promising approach for cancer treatment

Z Xu, S Zeng, Z Gong, Y Yan - Molecular cancer, 2020 - Springer
In the era of the rapid development of cancer immunotherapy, there is a high level of interest
in the application of cell-released small vesicles that stimulate the immune system. As cell …

Engineered extracellular vesicles and their mimetics for cancer immunotherapy

C Liu, Y Wang, L Li, D He, J Chi, Q Li, Y Wu… - Journal of Controlled …, 2022 - Elsevier
Extracellular vesicles (EVs) are heterogeneous membranous vesicles secreted by living
cells that are involved in many physiological and pathological processes as intermediaries …

Extracellular‐vesicle‐based drug delivery systems for enhanced antitumor therapies through modulating the cancer‐immunity cycle

T Yong, Z Wei, L Gan, X Yang - Advanced Materials, 2022 - Wiley Online Library
Although immunotherapy harnessing activity of the immune system against tumors has
made great progress, the treatment efficacy remains limited in most cancers. Current …

[HTML][HTML] Exosome regulation of immune response mechanism: Pros and cons in immunotherapy

JM Essola, M Zhang, H Yang, F Li, B **a… - Bioactive Materials, 2024 - Elsevier
Due to its multiple features, including the ability to orchestrate remote communication
between different tissues, the exosomes are the extracellular vesicles arousing the highest …

Modification of immune cell-derived exosomes for enhanced cancer immunotherapy: current advances and therapeutic applications

I Jung, S Shin, MC Baek, K Yea - Experimental & Molecular Medicine, 2024 - nature.com
Cancer immunotherapy has revolutionized the approach to cancer treatment of malignant
tumors by harnessing the body's immune system to selectively target cancer cells. Despite …

The exosomes derived from CAR-T cell efficiently target mesothelin and reduce triple-negative breast cancer growth

P Yang, X Cao, H Cai, P Feng, X Chen, Y Zhu… - Cellular …, 2021 - Elsevier
Genetically engineered T cells expressing a chimeric antigen receptor (CAR) have rapidly
developed into a powerful and innovative therapeutic modality for cancer patients. However …

Extracellular vesicles as next generation immunotherapeutics

DW Greening, R Xu, A Ale, CE Hagemeyer… - Seminars in Cancer …, 2023 - Elsevier
Extracellular vesicles (EVs) function as a mode of intercellular communication and
molecular transfer to elicit diverse biological/functional response. Accumulating evidence …

Immune cell-derived extracellular vesicles–new strategies in cancer immunotherapy

P Yang, Y Peng, Y Feng, Z Xu, P Feng, J Cao… - Frontiers in …, 2021 - frontiersin.org
Immune cell-derived extracellular vesicles (EVs) have increasingly become the focus of
research due to their unique characteristics and bioinspired applications. They are lipid …

The roles of small extracellular vesicles in cancer and immune regulation and translational potential in cancer therapy

K Qian, W Fu, T Li, J Zhao, C Lei, S Hu - Journal of Experimental & Clinical …, 2022 - Springer
Extracellular vesicles (EVs) facilitate the extracellular transfer of proteins, lipids, and nucleic
acids and mediate intercellular communication among multiple cells in the tumour …