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Recombinant human platelet-derived growth factor: biology and clinical applications
JO Hollinger, CE Hart, SN Hirsch, S Lynch… - JBJS, 2008 - journals.lww.com
The abilities of bone to remodel, fractures to repair, and bone grafts to incorporate are all
fundamental reflections of the bone remodeling cycle. This process is characterized by the …
fundamental reflections of the bone remodeling cycle. This process is characterized by the …
Fracture healing in the elderly patient
R Gruber, H Koch, BA Doll, F Tegtmeier… - Experimental …, 2006 - Elsevier
Clinical experience gives rise to the impression that there are differences in fracture healing
in different age groups. It is evident that fractures heal more efficiently in children than in …
in different age groups. It is evident that fractures heal more efficiently in children than in …
Genome-wide map** of Polycomb target genes unravels their roles in cell fate transitions
The Polycomb group (PcG) proteins form chromatin-modifying complexes that are essential
for embryonic development and stem cell renewal and are commonly deregulated in cancer …
for embryonic development and stem cell renewal and are commonly deregulated in cancer …
Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate
Under most conditions, resorbed bone is nearly precisely replaced in location and amount
by new bone. Thus, it has long been recognized that bone loss through osteoclast-mediated …
by new bone. Thus, it has long been recognized that bone loss through osteoclast-mediated …
BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development
The BMP signaling pathway has a crucial role in chondrocyte proliferation and maturation
during endochondral bone development. To investigate the specific function of the Bmp2 …
during endochondral bone development. To investigate the specific function of the Bmp2 …
The Sequential Expression Profiles of Growth Factors from Osteroprogenitors to Osteoblasts In Vitro
Z Huang, ER Nelson, RL Smith, SB Goodman - Tissue engineering, 2007 - liebertpub.com
In this study, we delineate the sequential expression of selected growth factors associated
with bone formation in vitro. Mineralization, osteocalcin, and alkaline phosphatase (ALP-2) …
with bone formation in vitro. Mineralization, osteocalcin, and alkaline phosphatase (ALP-2) …
Icariin induces osteogenic differentiation in vitro in a BMP-and Runx2-dependent manner
To effectively treat bone diseases using bone regenerative medicine, there is an urgent
need to develop safe cheap drugs that can potently induce bone formation. Here, we …
need to develop safe cheap drugs that can potently induce bone formation. Here, we …
Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation
Intraflagellar transport proteins (IFT) are required for hedgehog (Hh) signalling transduction
that is essential for bone development, however, how IFT proteins regulate Hh signalling in …
that is essential for bone development, however, how IFT proteins regulate Hh signalling in …
Statins and osteoporosis: new role for old drugs
SB Jadhav, GK Jain - Journal of pharmacy and pharmacology, 2006 - Wiley Online Library
Osteoporosis is the most common bone disease, affecting millions of people worldwide and
leading to significant morbidity and high expenditure. Most of the current therapies available …
leading to significant morbidity and high expenditure. Most of the current therapies available …
Bridging the regeneration gap: stem cells, biomaterials and clinical translation in bone tissue engineering
Advances in our understanding of skeletal stem cells and their role in bone development
and repair, offer the potential to open new frontiers in bone regeneration. Tissue …
and repair, offer the potential to open new frontiers in bone regeneration. Tissue …