Metal ions are essential to many chemical, biological, and environmental processes. In the
past two decades, many DNA-based metal sensors have emerged. While the main …

The ribosome is an ancient molecular fossil that provides a telescope to the origins of life.
Made from RNA and protein, the ribosome translates mRNA to coded protein in all living …

At the center of iron and oxidant metabolism is the ferritin superfamily: protein cages with
Fe2+ ion channels and two catalytic Fe/O redox centers that initiate the formation of caged …

Iron–sulfur clusters are ancient cofactors that play a fundamental role in metabolism and
may have impacted the prebiotic chemistry that led to life. However, it is unclear whether iron …

Metal ions provide considerable functionality across biological systems, and their utilization
within biomolecules has adapted through changes in the chemical environment to maintain …

SUMMARY In his 2001 article,“Translation: in retrospect and prospect,” the late Carl Woese
made a prescient observation that there was a need for the then-current view of translation …

Conspectus Central to the quest of understanding the emergence of life is to uncover the
role of metals, particularly iron, in sha** prebiotic chemistry. Iron, as the most abundant of …

The aim of this article is to provide the reader with an overview of the different possible
scenarios for the emergence of life, to critically assess them and, according to the …

Metal ions are ubiquitous elements within our environments. Their excessive accumulation
poses a great threat to human health. With the development of biology and bioanalytical …

The relationship between genetic molecules and metabolism is one of the longest-standing
problems for the origin of life. A central molecule within early metabolism is the coenzyme …