Haematological malignancies were previously thought to be driven solely by genetic or
epigenetic lesions within haematopoietic cells. However, the niches that maintain and …

The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …

Stroma is a poorly defined non-parenchymal component of virtually every organ with key
roles in organ development, homeostasis, and repair. Studies of the bone marrow stroma …

Processes of intraoperative diagnosis and elimination of tumors or micro-tumors or cancer
cells or tumor micro environment (TME) with plasmonic nanobubbles (PNBS) are disclosed …

Bone regeneration requires a well-orchestrated cellular and molecular response including
robust vascularization and recruitment of mesenchymal and osteogenic cells. In femoral …

Steady-state hematopoietic stem cells'(HSCs) self-renewal and differentiation toward their
mature progeny in the adult bone marrow is tightly regulated by cues from the …

Bone marrow endothelial cells (BMECs) form a network of blood vessels that regulate both
leukocyte trafficking and haematopoietic stem and progenitor cell (HSPC) maintenance …

The biology of haematopoietic stem cells (HSCs) has predominantly been studied under
transplantation conditions,. It has been particularly challenging to study dynamic HSC …

Haematopoietic stem cells (HSCs) reside in a perivascular niche but the specific location of
this niche remains controversial. HSCs are rare and few can be found in thin tissue sections …

Niches are local tissue microenvironments that maintain and regulate stem cells.
Haematopoiesis provides a model for understanding mammalian stem cells and their …