Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …

Diabesity is a term used to describe the combined adverse health effects of obesity and
diabetes mellitus. The worldwide dual epidemic of obesity and type 2 diabetes is an …

The alterations in myocardial energy substrate metabolism that occur in heart failure, and
the causes and consequences of these abnormalities, are poorly understood. There is …

Obesity and heart failure with preserved ejection fraction (HFpEF) represent two
intermingling epidemics driving perhaps the greatest unmet health problem in …

Excess lipid accumulation in non-adipose tissues is associated with insulin resistance,
pancreatic β-cell apoptosis and heart failure. Here, we demonstrate in cultured cells that the …

In recent years, diabetes mellitus has become an epidemic and now represents one of the
most prevalent disorders. Cardiovascular complications are the major cause of mortality and …

The endoplasmic reticulum (ER) is a cellular organelle important for regulating calcium
homeostasis, lipid metabolism, protein synthesis, and posttranslational modification and …

With nonalcoholic steatohepatitis (NASH), NASH cirrhosis, and NASH-related hepatocellular
carcinoma becoming increasingly prevalent, the need for effective therapies has never been …

The network for cardiac fuel metabolism contains intricate sets of interacting pathways that
result in both ATP-producing and non–ATP-producing end points for each class of energy …

A growing body of evidence highlights the close association between nutrition and human
health. Fat is an essential macronutrient, and vegetable oils, such as palm oil, are widely …