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Beyond the joints, the extra-articular manifestations in rheumatoid arthritis
Rheumatoid arthritis (RA) is an inflammatory disease typically affecting the joints, but the
systemic inflammatory process may involve other tissues and organs. Many extra-articular …
systemic inflammatory process may involve other tissues and organs. Many extra-articular …
Recent advances and evolving concepts in Still's disease
Still's disease is a rare inflammatory syndrome that encompasses systemic juvenile
idiopathic arthritis and adult-onset Still's disease, both of which can exhibit life-threatening …
idiopathic arthritis and adult-onset Still's disease, both of which can exhibit life-threatening …
HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19
Cytokine storm induced by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-
2) is a major pathological feature of Coronavirus Disease 2019 (COVID-19) and a crucial …
2) is a major pathological feature of Coronavirus Disease 2019 (COVID-19) and a crucial …
Tocilizumab in the treatment of rheumatoid arthritis: an evidence-based review and patient selection
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by articular and
systemic manifestations, such as anemia, fatigue, osteoporosis, and increased risk for …
systemic manifestations, such as anemia, fatigue, osteoporosis, and increased risk for …
Clinical and immunological parameters of Sjögren's syndrome
Sjögren's syndrome (SS) is a chronic autoimmune disease that primarily affects the exocrine
glands, resulting in their functional impairment. In SS, lymphocytic infiltration of salivary and …
glands, resulting in their functional impairment. In SS, lymphocytic infiltration of salivary and …
[HTML][HTML] Helicobacter pylori infection and autoimmune diseases; Is there an association with systemic lupus erythematosus, rheumatoid arthritis, autoimmune atrophy …
Autoimmune diseases are considered as one of the most important disorders of the immune
system, in which the prolonged and chronic processes eliminate self-tolerance to the auto …
system, in which the prolonged and chronic processes eliminate self-tolerance to the auto …
Failure of anti-TNF treatment in patients with rheumatoid arthritis: the pros and cons of the early use of alternative biological agents
The five TNF inhibitors currently approved for the treatment of RA are characterised by
differences in their molecular structures, half-lives, administration routes, dosing intervals …
differences in their molecular structures, half-lives, administration routes, dosing intervals …
Macrophages with regulatory functions, a possible new therapeutic perspective in autoimmune diseases
P Di Benedetto, P Ruscitti, Z Vadasz, E Toubi… - Autoimmunity …, 2019 - Elsevier
Macrophages are pivotal cells involved in chronic inflammatory and autoimmune diseases.
In fact, during these diseases, activated macrophages may play a critical role, promoting the …
In fact, during these diseases, activated macrophages may play a critical role, promoting the …
Guidelines for biomarkers in autoimmune rheumatic diseases-evidence based analysis
Autoimmune rheumatic diseases are characterised by an abnormal immune system
response, complement activation, cytokines dysregulation and inflammation. In last years …
response, complement activation, cytokines dysregulation and inflammation. In last years …
M281, an anti‐FcRn antibody: pharmacodynamics, pharmacokinetics, and safety across the full range of IgG reduction in a first‐in‐human study
LE Ling, JL Hillson, RG Tiessen, T Bosje… - Clinical …, 2019 - Wiley Online Library
M281 is a fully human, anti‐neonatal Fc receptor (FcRn) antibody that inhibits FcRn‐
mediated immunoglobulin G (IgG) recycling to decrease pathogenic IgG while preserving …
mediated immunoglobulin G (IgG) recycling to decrease pathogenic IgG while preserving …