Rigidity in mechanical biological networks

ML Manning - Current Biology, 2024 - cell.com
Multicellular organisms generate complex morphologies required for their function.
Organisms control these morphologies by tuning active forces and by altering the emergent …

Hydrodynamics of a twisting, bending, inextensible fiber in Stokes flow

O Maxian, B Sprinkle, CS Peskin, A Donev - Physical Review Fluids, 2022 - APS
In swimming microorganisms and the cell cytoskeleton, inextensible fibers resist bending
and twisting, and interact with the surrounding fluid to cause or resist large-scale fluid …

Endothelial cytoskeleton in mechanotransduction and vascular diseases

L **, Y Qin, Y Zhao, X Zhou, Y Zeng - Journal of Biomechanics, 2025 - Elsevier
The cytoskeleton is an important structural component that regulates various aspects of cell
morphology, movement, and intracellular signaling. It plays a pivotal role in the cellular …

[HTML][HTML] Fast Ewald summation for Stokes flow with arbitrary periodicity

J Bagge, AK Tornberg - Journal of Computational Physics, 2023 - Elsevier
A fast and spectrally accurate Ewald summation method for the evaluation of stokeslet,
stresslet and rotlet potentials of three-dimensional Stokes flow is presented. This work …

Size-dependent transition from steady contraction to waves in actomyosin networks with turnover

A Krishna, M Savinov, N Ierushalmi, A Mogilner… - Nature Physics, 2024 - nature.com
Actomyosin networks play essential roles in many cellular processes, including intracellular
transport, cell division and cell motility, and exhibit many spatiotemporal patterns. Despite …

Coarse-grained dynamics of transiently bound fast linkers

S Marbach, CE Miles - The Journal of Chemical Physics, 2023 - pubs.aip.org
Transient bonds between fast linkers and slower particles are widespread in physical and
biological systems. Despite their diverse structure and function, a commonality is that the …

A model for contractile stress fibers embedded in bulk actomyosin networks

M Savinov, CS Peskin, A Mogilner - arxiv preprint arxiv:2409.02282, 2024 - arxiv.org
Contractile cytoskeletal structures such as fine actomyosin meshworks and stress fibers are
essential force-generators for mechanical phenomena in live cells, including motility …

[HTML][HTML] Bending fluctuations in semiflexible, inextensible, slender filaments in Stokes flow: Toward a spectral discretization

O Maxian, B Sprinkle, A Donev - The Journal of Chemical Physics, 2023 - pubs.aip.org
Semiflexible slender filaments are ubiquitous in nature and cell biology, including in the
cytoskeleton, where reorganization of actin filaments allows the cell to move and divide …

Universally Adaptable Multiscale Molecular Dynamics (UAMMD). A native-GPU software ecosystem for complex fluids, soft matter, and beyond

RP Peláez, P Ibáñez-Freire, P Palacios-Alonso… - Computer Physics …, 2025 - Elsevier
Abstract We introduce UAMMD (Universally Adaptable Multiscale Molecular Dynamics), a
novel software infrastructure tailored for mesoscale complex fluid simulations on GPUs. The …

Interplay between Brownian motion and cross-linking controls bundling dynamics in actin networks

O Maxian, A Donev, A Mogilner - Biophysical journal, 2022 - cell.com
Morphology changes in cross-linked actin networks are important in cell motility, division,
and cargo transport. Here, we study the transition from a weakly cross-linked network of …