Mass spectrometry-based metabolomics in microbiome investigations

A Bauermeister, H Mannochio-Russo… - Nature Reviews …, 2022 - nature.com
Microbiotas are a malleable part of ecosystems, including the human ecosystem.
Microorganisms affect not only the chemistry of their specific niche, such as the human gut …

Microbiota succession throughout life from the cradle to the grave

C Martino, AH Dilmore, ZM Burcham… - Nature Reviews …, 2022 - nature.com
Associations between age and the human microbiota are robust and reproducible. The
microbial composition at several body sites can predict human chronological age relatively …

Multi-level analysis of the gut–brain axis shows autism spectrum disorder-associated molecular and microbial profiles

JT Morton, DM **, RH Mills, Y Shao, G Rahman… - Nature …, 2023 - nature.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by
heterogeneous cognitive, behavioral and communication impairments. Disruption of the gut …

Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma

KA Lee, AM Thomas, LA Bolte, JR Björk… - Nature Medicine, 2022 - nature.com
The composition of the gut microbiome has been associated with clinical responses to
immune checkpoint inhibitor (ICI) treatment, but there is limited consensus on the specific …

Microbiome differential abundance methods produce different results across 38 datasets

JT Nearing, GM Douglas, MG Hayes… - Nature …, 2022 - nature.com
Identifying differentially abundant microbes is a common goal of microbiome studies.
Multiple methods are used interchangeably for this purpose in the literature. Yet, there are …

Climate warming enhances microbial network complexity and stability

MM Yuan, X Guo, L Wu, YA Zhang, N **ao… - Nature Climate …, 2021 - nature.com
Unravelling the relationships between network complexity and stability under changing
climate is a challenging topic in theoretical ecology that remains understudied in the field of …

Estimated transmissibility and impact of SARS-CoV-2 lineage B. 1.1. 7 in England

NG Davies, S Abbott, RC Barnard, CI Jarvis… - Science, 2021 - science.org
INTRODUCTION Several novel variants of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), the virus that causes COVID-19, emerged in late 2020. One of these, Variant …

Analysis of compositions of microbiomes with bias correction

H Lin, SD Peddada - Nature communications, 2020 - nature.com
Differential abundance (DA) analysis of microbiome data continues to be a challenging
problem due to the complexity of the data. In this article we define the notion of “sampling …

Multigroup analysis of compositions of microbiomes with covariate adjustments and repeated measures

H Lin, SD Peddada - Nature Methods, 2024 - nature.com
Microbiome differential abundance analysis methods for two groups are well-established in
the literature. However, many microbiome studies involve more than two groups, sometimes …