The evolutionary expansion of the mammalian neocortex is widely considered to be a basis
of increased cognitive abilities. This expansion is a consequence of the enhanced …

The mammalian cerebral cortex is the pinnacle of brain evolution, reaching its maximum
complexity in terms of neuron number, diversity and functional circuitry. The emergence of …

Pathogenic mutant huntingtin (mHTT) infiltrates the adult Huntington's disease (HD) brain
and impairs fetal corticogenesis. However, most HD animal models rarely recapitulate …

Neurons populating the cerebral cortex are generated during embryonic development from
neural stem and progenitor cells in a process called neurogenesis. Neural stem and …

The evolutionary expansion of the mammalian brain, notably the neocortex, provides a
platform for the higher cognitive abilities that characterize humans. Cortical expansion is …

The concomitant occurrence of tissue growth and organization is a hallmark of organismal
development,–. This often means that proliferating and differentiating cells are found at the …

The expansion of brain size is accompanied by a relative enlargement of the subventricular
zone during development. Epithelial-like neural stem cells divide in the ventricular zone at …

Radial glial (RG) cells are the neural stem cells of the develo** neocortex. Apical RG
(aRG) cells can delaminate to generate basal RG (bRG) cells, a cell type associated with …

The cerebral cortex is a highly organized structure whose development depends on diverse
progenitor cell types, namely apical radial glia, intermediate progenitors, and basal radial …

Summary Phosphatidylinositol (PtdIns) transfer proteins (PITPs) stimulate PtdIns-4-P
synthesis and signaling in eukaryotic cells, but to what biological outcomes such signaling …