3D printed microfluidic devices: a review focused on four fundamental manufacturing approaches and implications on the field of healthcare
In the last few years, 3D printing has emerged as a promising alternative for the fabrication
of microfluidic devices, overcoming some of the limitations associated with conventional soft …
of microfluidic devices, overcoming some of the limitations associated with conventional soft …
Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling
PP Provenzano, PJ Keely - Journal of cell science, 2011 - journals.biologists.com
The notion that cell shape and spreading can regulate cell proliferation has evolved over
several years, but only recently has this been linked to forces from within and upon the cell …
several years, but only recently has this been linked to forces from within and upon the cell …
Geometric cues for directing the differentiation of mesenchymal stem cells
KA Kilian, B Bugarija, BT Lahn… - Proceedings of the …, 2010 - National Acad Sciences
Significant efforts have been directed to understanding the factors that influence the lineage
commitment of stem cells. This paper demonstrates that cell shape, independent of soluble …
commitment of stem cells. This paper demonstrates that cell shape, independent of soluble …
3D collagen alignment limits protrusions to enhance breast cancer cell persistence
Patients with mammographically dense breast tissue have a greatly increased risk of
develo** breast cancer. Dense breast tissue contains more stromal collagen, which …
develo** breast cancer. Dense breast tissue contains more stromal collagen, which …
Mechanobiology and developmental control
T Mammoto, A Mammoto… - Annual review of cell and …, 2013 - annualreviews.org
Morphogenesis is the remarkable process by which cells self-assemble into complex tissues
and organs that exhibit specialized form and function during embryological development …
and organs that exhibit specialized form and function during embryological development …
Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity
Osteoporosis, a condition of skeletal decline that undermines quality of life, is treated with
pharmacological interventions that are associated with poor adherence and adverse effects …
pharmacological interventions that are associated with poor adherence and adverse effects …
Mammary gland ECM remodeling, stiffness, and mechanosignaling in normal development and tumor progression
P Schedin, PJ Keely - Cold Spring Harbor perspectives …, 2011 - cshperspectives.cshlp.org
Cells of the mammary gland are in intimate contact with other cells and with the extracellular
matrix (ECM), both of which provide not only a biochemical context, but a mechanical …
matrix (ECM), both of which provide not only a biochemical context, but a mechanical …
Mechanical regulation of signaling pathways in bone
A wide range of cell types depend on mechanically induced signals to enable appropriate
physiological responses. The skeleton is particularly dependent on mechanical information …
physiological responses. The skeleton is particularly dependent on mechanical information …
An injury-responsive Rac-to-Rho GTPase switch drives activation of muscle stem cells through rapid cytoskeletal remodeling
Many tissues harbor quiescent stem cells that are activated upon injury, subsequently
proliferating and differentiating to repair tissue damage. Mechanisms by which stem cells …
proliferating and differentiating to repair tissue damage. Mechanisms by which stem cells …
Directing osteogenic and myogenic differentiation of MSCs: interplay of stiffness and adhesive ligand presentation
AS Rowlands, PA George… - American Journal of …, 2008 - journals.physiology.org
The mechanical properties of the extracellular matrix (ECM) can exert significant influence in
determining cell fate. Human mesenchymal stem cells (MSCs) grown on substrates with …
determining cell fate. Human mesenchymal stem cells (MSCs) grown on substrates with …