The integrated stress response (ISR) triggered in response to various cellular stress enables
mammalian cells to effectively cope with diverse stressful conditions while maintaining their …

Eukaryotic initiation factor 2B, eIF2B is a guanine nucleotide exchange, factor with a central
role in coordinating the initiation of translation. During stress and disease, the activity of …

Ribosome profiling, which is based on deep sequencing of ribosome footprints, has served
as a powerful tool for elucidating the regulatory mechanism of protein synthesis. However …

In higher eukaryotes, tRNA methyltransferase 10A (TRMT10A) is responsible for N1-
methylguanosine modification at position nine of various cytoplasmic tRNAs. Pathogenic …

Small-molecule compounds that elicit mRNA-selective translation repression have attracted
interest due to their potential for expansion of druggable space. However, only a limited …

Viral infection triggers activation of the integrated stress response (ISR). In response to viral
double-stranded RNA (dsRNA), RNA-activated protein kinase (PKR) phosphorylates the …

Introduction Biomarkers play a crucial role across various fields by providing insights into
biological responses to interventions. High-throughput gene expression profiling …

Control of protein synthesis (mRNA translation) plays key roles in sha** the proteome and
in many physiological, including homeostatic, responses. One long-known translational …

Highlights•The integrated stress response (ISR) is an adaptive pathway activated by various
stressors, including virus infection.•ISR activation culminates in translation arrest through …

Mitochondria possess their own genome that encodes components of oxidative
phosphorylation (OXPHOS) complexes, and mitochondrial ribosomes within the organelle …